The impact of miRNAs on epithelial-mesenchymal transition in lung cancer and the latest advances in their use as diagnostic markers.

Abstract

Purpose: Lung cancer is currently the most common malignant tumor worldwide and one of the leading causes of cancer-related deaths, posing a serious threat to human health. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNA molecules that regulate gene expression and are involved in various biological processes associated with lung cancer. Understanding the mechanisms of lung carcinogenesis and detecting disease biomarkers may enable early diagnosis of lung cancer.

Methods: Epithelial-mesenchymal transition (EMT) is a critical biological process through which tumor cells acquire migratory and invasive capabilities, playing an important role in the progression of lung cancer. miRNAs regulate the EMT process in lung cancer cells by targeting transcription factors such as Snail, Slug, and ZEB1/2, as well as modulating signaling pathways including TGF-β and Wnt/β-catenin, thereby enhancing their migratory and invasive abilities.

Results: NSCLC has been comprehensively elucidated in terms of its pathogenesis, and the detection and therapeutic approaches targeting miRNAs for NSCLC have been systematically summarized.

Conclusion: This review examines the impact of miRNAs on tumor invasiveness through the regulation of key factors or signaling pathways, as well as their potential as biomarkers for the early diagnosis of lung cancer. It provides a theoretical foundation for studying the mechanisms of lung cancer metastasis and developing more precise detection and treatment strategies.