Molecular signatures of breast cancer in the Iranian population: a review of cell growth and cell cycle regulators.

IF 2.8 3区 医学 Q3 ONCOLOGY
Zeynab Mashayekh, Jalal Vallian Broojeni, Rasool Fatehi Fard, Sadeq Vallian
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引用次数: 0

Abstract

The mortality rate of breast cancer remains relatively high in the Iranian population, with approximately 4810 deaths reported in 2020 (GLOBOCAN). This elevated fatality rate has been predominantly attributed to delays in diagnosis. In recent years, substantial research efforts have been directed toward elucidating cellular markers associated with breast cancer within this population. To this end, a systematic literature search was undertaken across both international and national databases, including PubMed, Scopus, IranMedex, and Magiran, covering the period from 2019 to 2024. The review synthesized data from studies encompassing a total of 15,318 Iranian breast cancer patients. The aggregated evidence provides comprehensive insights into cellular growth and cell cycle regulation markers implicated in breast cancer, thereby offering potential to inform the development of population-specific molecular diagnostic and prognostic strategies.

Abstract Image

伊朗人群乳腺癌的分子特征:细胞生长和细胞周期调节因子的综述。
在伊朗人口中,乳腺癌的死亡率仍然相对较高,2020年报告的死亡人数约为4810人(GLOBOCAN)。死亡率的升高主要是由于诊断的延误。近年来,大量的研究工作已经指向阐明与乳腺癌相关的细胞标志物在这一人群。为此,在国际和国内数据库中进行了系统的文献检索,包括PubMed、Scopus、IranMedex和Magiran,检索时间为2019年至2024年。该综述综合了来自15,318名伊朗乳腺癌患者的研究数据。这些综合证据提供了与乳腺癌相关的细胞生长和细胞周期调节标志物的全面见解,从而为人群特异性分子诊断和预后策略的发展提供了潜在的信息。
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来源期刊
CiteScore
4.00
自引率
2.80%
发文量
577
审稿时长
2 months
期刊介绍: The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.
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