{"title":"Molecular signatures of breast cancer in the Iranian population: a review of cell growth and cell cycle regulators.","authors":"Zeynab Mashayekh, Jalal Vallian Broojeni, Rasool Fatehi Fard, Sadeq Vallian","doi":"10.1007/s00432-025-06301-y","DOIUrl":null,"url":null,"abstract":"<p><p>The mortality rate of breast cancer remains relatively high in the Iranian population, with approximately 4810 deaths reported in 2020 (GLOBOCAN). This elevated fatality rate has been predominantly attributed to delays in diagnosis. In recent years, substantial research efforts have been directed toward elucidating cellular markers associated with breast cancer within this population. To this end, a systematic literature search was undertaken across both international and national databases, including PubMed, Scopus, IranMedex, and Magiran, covering the period from 2019 to 2024. The review synthesized data from studies encompassing a total of 15,318 Iranian breast cancer patients. The aggregated evidence provides comprehensive insights into cellular growth and cell cycle regulation markers implicated in breast cancer, thereby offering potential to inform the development of population-specific molecular diagnostic and prognostic strategies.</p>","PeriodicalId":15118,"journal":{"name":"Journal of Cancer Research and Clinical Oncology","volume":"151 9","pages":"255"},"PeriodicalIF":2.8000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426308/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cancer Research and Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00432-025-06301-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The mortality rate of breast cancer remains relatively high in the Iranian population, with approximately 4810 deaths reported in 2020 (GLOBOCAN). This elevated fatality rate has been predominantly attributed to delays in diagnosis. In recent years, substantial research efforts have been directed toward elucidating cellular markers associated with breast cancer within this population. To this end, a systematic literature search was undertaken across both international and national databases, including PubMed, Scopus, IranMedex, and Magiran, covering the period from 2019 to 2024. The review synthesized data from studies encompassing a total of 15,318 Iranian breast cancer patients. The aggregated evidence provides comprehensive insights into cellular growth and cell cycle regulation markers implicated in breast cancer, thereby offering potential to inform the development of population-specific molecular diagnostic and prognostic strategies.
期刊介绍:
The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses.
The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.