Dietary vitamin E intake in metabolic dysfunction-associated steatotic liver disease and all-cause/cause-specific mortality.

IF 1.8 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2025-08-20 DOI:10.1097/MEG.0000000000003065

Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Aijaz Ahmed

{"title":"Dietary vitamin E intake in metabolic dysfunction-associated steatotic liver disease and all-cause/cause-specific mortality.","authors":"Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Aijaz Ahmed","doi":"10.1097/MEG.0000000000003065","DOIUrl":null,"url":null,"abstract":"Aims: We investigated the independent association between dietary vitamin E intake among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and all-cause and cause-specific mortality in a representative sample of the USA.Methods: We used the 2007-2014 US National Health and Nutrition Examination Survey with mortality follow-up through 2019 (median: 8.6 years). Cox regression models were used to assess the association between dietary vitamin E intake in MASLD and all-cause and cause-specific mortality.Results: Among the 10 193 individuals with MASLD (mean age: 46.8 years and male: 48.0%), greater dietary vitamin E intake was correlated with a gradual reduction in the risk of all-cause mortality, which remained significant after adjustment for clinical and metabolic risk factors (hazard ratio: 0.68, 95% confidence interval: 0.50-0.94 for the fourth quartile compared with the first quartile; P for trend = 0.018). This association remained more pronounced in older populations, males, and non-Hispanic Whites than in their counterparts. Increased dietary vitamin E intake demonstrated trends associated with reduced cancer-related mortality.Conclusion: Higher dietary vitamin E intake in MASLD was associated with a lower risk of all-cause mortality.","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Gastroenterology & Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MEG.0000000000003065","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: We investigated the independent association between dietary vitamin E intake among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and all-cause and cause-specific mortality in a representative sample of the USA.

Methods: We used the 2007-2014 US National Health and Nutrition Examination Survey with mortality follow-up through 2019 (median: 8.6 years). Cox regression models were used to assess the association between dietary vitamin E intake in MASLD and all-cause and cause-specific mortality.

Results: Among the 10 193 individuals with MASLD (mean age: 46.8 years and male: 48.0%), greater dietary vitamin E intake was correlated with a gradual reduction in the risk of all-cause mortality, which remained significant after adjustment for clinical and metabolic risk factors (hazard ratio: 0.68, 95% confidence interval: 0.50-0.94 for the fourth quartile compared with the first quartile; P for trend = 0.018). This association remained more pronounced in older populations, males, and non-Hispanic Whites than in their counterparts. Increased dietary vitamin E intake demonstrated trends associated with reduced cancer-related mortality.

Conclusion: Higher dietary vitamin E intake in MASLD was associated with a lower risk of all-cause mortality.

查看原文本刊更多论文

膳食维生素E摄入与代谢功能障碍相关的脂肪变性肝病和全因/病因特异性死亡率的关系

目的：我们调查了美国代表性样本中代谢功能障碍相关脂肪变性肝病（MASLD）患者膳食维生素E摄入量与全因和病因特异性死亡率之间的独立关系。方法：我们使用2007-2014年美国国家健康和营养检查调查，并随访至2019年（中位数：8.6岁）。Cox回归模型用于评估MASLD患者膳食维生素E摄入量与全因死亡率和病因特异性死亡率之间的关系。结果：在10 193例MASLD患者（平均年龄46.8岁，男性48.0%）中，饮食中维生素E摄入量的增加与全因死亡风险的逐渐降低相关，在调整临床和代谢危险因素后，这一趋势仍然显著（第四四分位数与第一四分位数的风险比为0.68,95%置信区间为0.50-0.94；趋势P = 0.018）。这种关联在老年人、男性和非西班牙裔白人中更为明显。饮食中维生素E摄入量的增加显示出与降低癌症相关死亡率相关的趋势。结论：高膳食维生素E摄入量与低全因死亡率相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.