Rutin alleviates lipopolysaccharide-induced neuroinflammation and blood brain barrier dysfunction

IF 2.6 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-09-08 DOI:10.1016/j.brainres.2025.149941

Yuanyuan Meng , Xingyu Liu , Ding Ding , Jingrong Wang , Jian Mao , Le Kang , Lili Cao

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引用次数: 0

Abstract

The blood–brain barrier (BBB) plays a pivotal role in safeguarding and sustaining the brain’s microenvironment. Disruption of this barrier is commonly observed in various neurological disorders and is intricately linked with neuroinflammation. Rutin, a natural flavonoid known for its diverse biological activities, has showed protective effects against neuroinflammation. However, its anti-neuroinflammation role and potential to preserve the integrity of the BBB has yet to be fully elucidated. In the present study, we investigated the effects of rutin against lipopolysaccharide (LPS)-induced neuroinflammation and BBB dysfunction. The results showed that rutin pretreatment effectively mitigated LPS-induced BBB disruption and inflammatory changes in the mice brain. Mechanistically, rutin inhibited LPS-induced microglial activation and decreased the production of pro-inflammatory cytokines primarily via the caspase-mediated non-canonical inflammatory signaling pathway. These findings highlight rutin as a promising therapeutic candidate for alleviating neuroinflammation related neurological disorders.

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芦丁可减轻脂多糖诱导的神经炎症和血脑屏障功能障碍。

血脑屏障（BBB）在保护和维持大脑微环境方面起着关键作用。这种屏障的破坏通常在各种神经系统疾病中观察到，并且与神经炎症有着复杂的联系。芦丁是一种天然类黄酮，具有多种生物活性，对神经炎症有保护作用。然而，其抗神经炎症作用和保持血脑屏障完整性的潜力尚未完全阐明。在本研究中，我们研究了芦丁对脂多糖（LPS）诱导的神经炎症和血脑屏障功能障碍的影响。结果表明，芦丁预处理能有效减轻lps诱导的小鼠脑血脑屏障破坏和炎症变化。在机制上，芦丁主要通过caspase介导的非典型炎症信号通路抑制lps诱导的小胶质细胞活化并减少促炎细胞因子的产生。这些发现突出了芦丁作为缓解神经炎症相关神经系统疾病的有希望的治疗候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.