Sean P Langan, Emily C Tagesen, Steven D Landspurg, Peter S Figueiredo, Quint N Berkemeier, Melissa D McInnis, Robert L Alunday, Aaron J Reilly, Trevor J Mayschak, Erik R Swenson, Pierre A Fabries, Jon K Femling, Beth A Beidleman
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引用次数: 0
Abstract
Insulin resistance has been associated with acute mountain sickness (AMS) risk, but the influence of active ascent is unclear.
Methods: Thirty-two unacclimatized Soldiers (23±4yr; 80±14 kg) were tested at baseline residence (BLR), hiked ~5 km (n=16) or were driven (n=16) to 4,300 m, and stayed for 4 days (~66 h). Venous blood was taken each morning at BLR and during high altitude (HA) exposure days 2-4 (HA2-4) and the evening on day 1 at HA (HA1). Metabolites and hormones were measured, and insulin resistance (HOMA-IR) was calculated. AMS cerebral factor score (AMS-C) was measured daily and peak scores were calculated.
Results: Active ascenders had higher energy expenditure (1,265±351 vs. 408±208 kcal) and lower oxygen saturation (SpO2) (75±3 vs. 82±3%) during ascent. Norepinephrine and lactate were higher (P<0.007) in active ascenders on HA1. All other data were combined due to lack of group differences. Glucose, insulin, and HOMA-IR were elevated (P<0.05) on HA2 (105.9 ± 12.3 mg/dl; 12.1 ± 6.8 μIU/ml; 3.2 ± 2.1 au) and HA3 (101.8 ± 11.2 mg/dl; 10.2 ± 5.5 μIU/ml; 2.2±1.4 au) versus baseline and returned to normal on HA4. Epinephrine (P<0.001) and cortisol (P=0.004) were elevated on HA1 and HA2 versus baseline, respectively. GLP-1 was higher on HA1 versus HA2 and HA3 (P<0.021). Glucose (rrm=0.42; P=0.001), insulin (rrm=0.29; P=0.001), HOMA-IR (rrm=0.27; P=0.002), epinephrine (rrm=0.34; P<0.001), and norepinephrine (rrm=0.20; P=0.027) were significantly correlated with AMS-C.
Conclusions: Transient perturbations to glucose metabolism during 4 days of HA exposure influences AMS severity without further impact from active ascent.
期刊介绍：
The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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