Strategic advances in C-OCF3 bond transformations.

Abstract

While synthetic developments for the synthesis of trifluoromethoxylated arenes have flourished over the years, the cleavage of a C-OCF₃ bond remains a niche topic and a synthetic challenge to overcome. This review provides an overview of major advances made in activating a strong aryl C-OCF₃ bond, enabling C-C, C-H, and C-Heteroatom bond formations. These advances underscore the transformative potential of further developments in this emerging field.