Femtosecond-Laser-Assisted Liquid-Interface vs Vacuum-Trephine Keratoplasty: A Comparison of 2 Different Techniques - Retrospective Data Analysis.

Clinical ophthalmology (Auckland, N.Z.) Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI:10.2147/OPTH.S542124

Michal Klimek, Irene Steiner, Ruth Donner, Christian Skorpik, Julia Aschauer, Gerald Schmidinger, Jan Lammer

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Abstract

Purpose: To compare postoperative astigmatism and visual acuity (VA) outcomes in patients undergoing penetrating keratoplasty (PK) using a liquid-interface femtosecond laser (LI-fs) trephination and a conventional vacuum-trephine (VT) technique.

Methods: Our single-center, retrospective data analysis included 121 eyes (121 patients) treated between April 2014 and November 2022. Patients received PK either with a LI-fs or a VT system. Pre- and postoperative topography (K-values), refraction (cylinder) and visual acuity (VA) were measured up to 18 months after surgery. Data were analyzed by descriptive statistics, ANCOVA, and paired t-tests within each group.

Results: Preoperative and postoperative astigmatism were similar between the two techniques (LI-fs: 5.4 ± 3.4 D pre-OP vs 6.7 ± 4.2 D post-OP; VT group: 5.8 ± 4.8 D vs 6.7 ± 3.8D). An ANCOVA adjusting for baseline astigmatism (=∆K in topography imaging) revealed no statistically significant difference between groups (estimate [95% CI]: -0.79 [-2.73; 1.15], p = 0.42). Within-group changes in astigmatism were also not significant. For VA, a paired t-test showed a significant increase of post-OP VA in the VT group (mean change 0.25 [0.15; 0.34], p < 0.0001), while the smaller LI-fs group showed no significant change (mean 0.16 [-0.11; 0.44], p = 0.22).

Conclusion: Despite the characteristics of LI-fs in maintaining corneal curvature, LI-fs and conventional VT generated comparable outcomes in terms of post-OP astigmatism. The results underscore the need for further research with larger cohorts to clarify any potential advantages of the LI-fs in reducing surgically-induced astigmatism.

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飞秒激光辅助液界面与真空环钻角膜移植术：两种不同技术的比较-回顾性数据分析。

目的：比较液体界面飞秒激光（LI-fs）环钻术与传统真空环钻术（VT）穿透性角膜移植术（PK）患者术后散光和视力（VA）的影响。方法：我们的单中心回顾性数据分析包括2014年4月至2022年11月期间治疗的121只眼睛（121例患者）。患者接受PK时采用LI-fs或VT系统。术后18个月测量术前和术后地形图（k值）、屈光（圆柱体）和视力（VA）。每组数据采用描述性统计、方差分析和配对t检验进行分析。结果：两种技术术前和术后散光相似（LI-fs：术前5.4±3.4 D vs术后6.7±4.2 D； VT组：5.8±4.8 D vs术后6.7±3.8D）。经ANCOVA校正基线散光（地形成像=∆K），各组间无统计学差异（估计[95% CI]: -0.79 [-2.73; 1.15], p = 0.42）。组内散光变化也不显著。对于VA，配对t检验显示VT组术后VA显著升高（平均变化0.25 [0.15;0.34],p < 0.0001），而较小LI-fs组无显著变化（平均变化0.16 [-0.11;0.44],p = 0.22）。结论：尽管LI-fs具有维持角膜曲率的特点，但在术后散光方面，LI-fs和传统VT的结果相当。研究结果强调了进一步研究的必要性，需要更大的队列来阐明LI-fs在减少手术引起的散光方面的任何潜在优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical ophthalmology (Auckland, N.Z.)

CiteScore

4.10

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0.00%

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