Elena Castellano, Anna Garelli, Roberto Attanasio, Alberto Boriano, Giorgio Borretta
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引用次数: 0
Abstract
Background: While osteoporosis in primary hyperparathyroidism (PHPT) is widely studied, PHPT patients with osteopenia remain less characterized. This study aimed to evaluate the prevalence, biochemical features, and estimated fracture risk of osteopenic PHPT patients in a real-life cohort.
Methods: We retrospectively analyzed a consecutive series of PHPT patients with available densitometric data at three sites. Postmenopausal women and men over 50 years old with PHPT and osteopenia were selected. FRAX scores were used to estimate fracture risk, and subgroup analyses were conducted based on sex, age, and PHPT clinical presentation.
Results: One hundred out of 439 PHPT patients (22.8%) were osteopenic. As compared to osteopenic women, osteopenic men were older (p = 0.03), had higher BMD at the spine and femoral neck (p = 0.007 and p = 0.006, respectively), and more frequent occurrence of nephrolithiasis (p = 0.046). Osteopenic patients older than 65 years had worst FRAX scores and higher prevalence of comorbidities, as type 2 diabetes and hypertension, than their younger counterparts (both p < 0.001). FRAX scores of osteopenic PHPT patients were not different according to their clinical classification of PHPT.
Conclusions: Patients with osteopenia account for about one fifth of our whole series and two thirds of them met surgical indication according to latest international guidelines. Neither densitometric data nor estimated fracture risk differed between osteopenic PHPT patients meeting or not surgical criteria.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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