Expanded field OCTA Biomarkers Associated with the Development of Tractional Retinal Detachment in Proliferative Diabetic Retinopathy.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-03 DOI:10.1097/IAE.0000000000004661

Edward S Lu, Yifan Lu, Ying Cui, Rebecca Zeng, Ying Zhu, Xinyi Ding, Raviv Katz, Rongrong Le, Itika Garg, Jay C Wang, Demetrios G Vavvas, Deeba Husain, Joan W Miller, David M Wu, John B Miller

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引用次数: 0

Abstract

Purpose: To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).

Methods: Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders. A logistic regression model was utilized to identify OCTA biomarkers associated with TRD development.

Results: Forty-nine PDR eyes from 38 participants were included. Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.

Conclusion: Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. SS-OCTA may be useful for predicting diabetic TRD development.

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扩展视野OCTA生物标志物与增生性糖尿病视网膜病变牵引性视网膜脱离的发展相关。

目的：探讨增生性糖尿病视网膜病变（PDR）患者扩展场扫描源光学相干断层血管造影（SS-OCTA）生物标志物与牵引性视网膜脱离（TRD）发生的关系。方法：对基线无TRD的PDR患者进行SS-OCTA成像。定量和定性OCTA指标由两名训练有素的评分员独立评估。采用逻辑回归模型鉴定与TRD发展相关的OCTA生物标志物。结果：包括38名参与者的49只PDR眼。49只眼中有7只（14%）在中位576天（范围35-805天）内发生TRD。与TRD相关的生物标志物有：视网膜非灌注面积大（NPA）（优势比[OR]， 7.84； 95%可信区间[CI]， 2.61 - 16.3; p = 0.04），新生血管（NV）的存在，总面积为bbbb4盘直径，（OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04），以及出现tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02)，定义为NV通过玻璃体牵引前移位，但通过血管膜系在视网膜上。结论：视网膜NPA大、NV广泛、NV伴玻璃体牵拉前移位与TRD发生风险增加有关。SS-OCTA可能有助于预测糖尿病TRD的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.