LARGE RETINAL CAPILLARY ANEURYSM: CLINICAL FEATURES, MULTIMODAL IMAGING CHARACTERISTICS AND TREATMENT OUTCOMES OF PRIMARY AND SECONDARY LESIONS.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2025-09-03 DOI:10.1097/IAE.0000000000004665

Kemal Tekin, Mehmet Ali Sekeroglu, Sibel Doguizi, Cemile Ucgul Atilgan, Merve Inanc, Mehmet Fatih Kagan Degirmenci, Hilal Kılınc Hekimsoy, Mehmet Yasin Teke

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Abstract

Purpose: To compare the clinical features, multimodal imaging characteristics, and treatment outcomes of primary and secondary large retinal capillary aneurysms (LRCA).

Methods: A total of 34 eyes were included: seven with primary LRCA and 27 with secondary LRCA. All patients underwent fundus photography, optical coherence tomography (OCT), and fundus fluorescein angiography. Indocyanine green angiography and OCT-angiography were performed in selected cases. Various clinical, morphological, and vascular features and treatment outcomes were evaluated and compared between the primary and secondary LRCA groups.

Results: All lesions in the primary LRCA group were unilateral, and five of seven were unifocal. However, in the secondary LRCA group, 19% of patients had bilateral involvement and lesions were multifocal in 48% of eyes. OCT characteristics, including the horizontal and vertical diameters of aneurysmal lesions and mean subfoveal choroidal thickness, were similar for the groups (p>0.05). During follow-up, neither visual acuity nor central macular thickness changed significantly in the primary LRCA group and no cases responded to treatment, whereas these improved significantly in the secondary LRCA group.

Conclusion: Clinical and imaging characteristics of primary and secondary LRCA lesions were similar, although treatment outcomes were more favorable in secondary LRCA lesions due to the differing pathophysiology and etiology.

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大视网膜毛细血管动脉瘤：原发和继发病变的临床特征、多模态影像学特征及治疗结果。

目的：比较原发性和继发性视网膜大毛细血管动脉瘤（large retinal毛细血管动脉瘤，LRCA）的临床特点、多模态影像学特征及治疗效果。方法：34只眼：7只眼为原发性LRCA， 27只眼为继发性LRCA。所有患者均接受眼底摄影、光学相干断层扫描（OCT）和眼底荧光素血管造影。选择病例行吲哚菁绿血管造影和oct血管造影。评估和比较原发性和继发性LRCA组的各种临床、形态学和血管特征和治疗结果。结果：原发性LRCA组所有病变均为单侧病变，7例中5例为单灶性病变。然而，在继发性LRCA组中，19%的患者有双侧受累，48%的患者有多灶性病变。OCT特征，包括动脉瘤病变的水平和垂直直径和平均中央凹下脉络膜厚度，各组相似（p>0.05）。随访期间，原发性LRCA组的视力和黄斑中央厚度均无明显变化，治疗无应答，而继发性LRCA组的视力和黄斑中央厚度均有显著改善。结论：原发性和继发性LRCA病变的临床和影像学特征相似，但继发性LRCA病变由于病理生理和病因不同，治疗结果更有利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.