{"title":"Targeting cholesterol-dependent adrenal steroidogenesis for management of primary aldosteronism.","authors":"Hao Wu, Hongbo He, Tong Han, Xiaoyu Tian, Zhiming Zhu","doi":"10.1016/j.tem.2024.12.001","DOIUrl":null,"url":null,"abstract":"<p><p>Primary aldosteronism (PA) is a common, salt-sensitive form of endocrine hypertension. Compared with essential hypertension (EH), PA is more susceptible to cardiorenal complications and metabolic risks. However, PA has a low screening rate and a poor response to mineralocorticoid receptor antagonists (MRAs). In addition to somatic ion channel mutations and epigenetic alterations, which contribute to excessive production of aldosterone, cholesterol, as a crucial precursor for aldosterone biosynthesis, may be involved in PA pathogenesis. Abnormal adrenal cholesterol uptake and steroidogenesis have been found in patients with PA. Therefore, we propose that a statin-based therapeutic strategy may be pivotal for antagonizing PA-related comorbidities by targeting cholesterol-dependent adrenal steroidogenesis.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":"36 9","pages":"789-801"},"PeriodicalIF":12.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tem.2024.12.001","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Primary aldosteronism (PA) is a common, salt-sensitive form of endocrine hypertension. Compared with essential hypertension (EH), PA is more susceptible to cardiorenal complications and metabolic risks. However, PA has a low screening rate and a poor response to mineralocorticoid receptor antagonists (MRAs). In addition to somatic ion channel mutations and epigenetic alterations, which contribute to excessive production of aldosterone, cholesterol, as a crucial precursor for aldosterone biosynthesis, may be involved in PA pathogenesis. Abnormal adrenal cholesterol uptake and steroidogenesis have been found in patients with PA. Therefore, we propose that a statin-based therapeutic strategy may be pivotal for antagonizing PA-related comorbidities by targeting cholesterol-dependent adrenal steroidogenesis.
期刊介绍：
Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage.
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