A Holistic Approach to AKI: Integrating Clinical and Molecular Data in the Human Kidney.

IF 3.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2025-09-08 DOI:10.1016/j.semnephrol.2025.151663

Jennifer A Schaub, Mathew Alaba, Matthias Kretzler

引用次数: 0

Abstract

Despite intensive research efforts, acute kidney injury (AKI) is a common clinical syndrome that has limited treatment options apart from supportive care. The increasing availability of molecular interrogation data from patients with Acute Kidney Injury provides an unparalleled opportunity to leverage systems biology approaches. In this review, we discuss the challenges with AKI research, explain how systems biology approaches can link molecular data to clinical phenotypes, review available molecular interrogation tools and techniques, and provide examples where systems biology approaches have been successfully applied in nephrology. Semin Nephrol 36:x-xx © 20XX Elsevier Inc. All rights reserved.

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AKI的整体方法：整合人类肾脏的临床和分子数据。

尽管进行了大量的研究，急性肾损伤（AKI）是一种常见的临床综合征，除了支持性护理外，治疗选择有限。来自急性肾损伤患者的分子询问数据的日益增加的可用性为利用系统生物学方法提供了无与伦比的机会。在这篇综述中，我们讨论了AKI研究面临的挑战，解释了系统生物学方法如何将分子数据与临床表型联系起来，回顾了可用的分子询问工具和技术，并提供了系统生物学方法成功应用于肾脏病学的例子。Semin Nephrol 36:x-xx©20XX Elsevier Inc.。版权所有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.