Smaller hippocampal tail volume is associated with plasma CCL11 levels in patients with major depressive disorder.

IF 5.5 2区医学 Q1 PSYCHIATRY

Psychological Medicine Pub Date : 2025-09-10 DOI:10.1017/S0033291725101402

Longhai Wu, Yilin Liu, Lingtao Kong, Xintong Yan, Yihui Lu, Xiaowei Jiang, Yifang Zhou, Qikun Sun, Feng Wu

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引用次数: 0

Abstract

Background: This study investigates structural abnormalities in hippocampal subfield volumes and shapes, and their association with plasma CC chemokines in individuals with major depressive disorder (MDD).

Methods: A total of 61 patients with MDD and 65 healthy controls (HC) were recruited. All participants underwent high-resolution T1-weighted imaging and provided blood samples for the detection of CC chemokines (CCL2, CCL7, and CCL11). Comparisons of hippocampal subregion volumes, surface shapes, and plasma CC chemokine concentrations were conducted between the MDD and HC groups. Furthermore, partial correlation analysis was performed to assess the relationship between structural abnormalities (hippocampal subfield volume and shape) and plasma CC chemokine levels.

Results: The MDD group exhibited a significant reduction in the volume of the left hippocampal tail compared to the HC group (F = 9.750, Bonferroni-corrected p = 0.026). No significant outward or inward deformation of the hippocampus was detected in MDD patients relative to the HC group (all FWE-corrected p > 0.05). Additionally, plasma CCL11 levels were elevated in the MDD group compared to the HC group (F = 9.982, p = 0.002), with these levels showing a positive correlation with the duration of the illness (r = 0.279, p = 0.029). Partial correlation analysis further revealed a negative correlation between the smaller left hippocampal tail volume and plasma CCL11 levels in MDD patients (r = -0.416, p = 0.001).

Conclusion: Abnormally elevated plasma CCL11 in MDD patients may mediate damage to specific hippocampal substructures.

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重度抑郁症患者海马尾体积变小与血浆CCL11水平相关

背景：本研究探讨了重度抑郁症（MDD）患者海马亚区体积和形状的结构异常及其与血浆CC趋化因子的关系。方法：共招募61例重度抑郁症患者和65例健康对照（HC）。所有参与者均接受高分辨率t1加权成像，并提供血液样本用于检测CC趋化因子（CCL2、CCL7和CCL11）。比较MDD组和HC组海马亚区体积、表面形状和血浆CC趋化因子浓度。此外，进行部分相关分析以评估结构异常（海马亚区体积和形状）与血浆CC趋化因子水平之间的关系。结果：与HC组相比，MDD组左侧海马尾体积显著减少（F = 9.750， bonferroni校正p = 0.026）。与HC组相比，MDD患者海马未出现明显的向外或向内变形（均为fwe校正p < 0.05）。此外，与HC组相比，MDD组血浆CCL11水平升高（F = 9.982, p = 0.002），这些水平与疾病持续时间呈正相关（r = 0.279, p = 0.029）。偏相关分析进一步显示，MDD患者左海马尾体积变小与血浆CCL11水平呈负相关（r = -0.416, p = 0.001）。结论：MDD患者血浆CCL11异常升高可能介导特异性海马亚结构损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychological Medicine 医学-精神病学

CiteScore

11.30

自引率

4.30%

发文量

711

审稿时长

3-6 weeks

期刊介绍： Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.