Unravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective.

IF 9.2 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-09-09 DOI:10.1038/s41522-025-00816-5

Hannah H Rashwan, Nour H Marzouk, Rana A Youness, Mohamed El-Hadidi, Raghda Ramadan, Mohamed Mysara

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Abstract

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC), accounting for nearly 40% of BC-related deaths. Emerging evidence suggests that the breast tissue microbiome harbors distinct microbial communities; however, the microbiome specific to TNBC remains largely unexplored. This study presents the first comprehensive meta-analysis of the TNBC tissue microbiome, consolidating 16S rRNA amplicon sequencing data from 200 BC samples across four independent cohorts. Our analysis highlights the enrichment of Azospirillum genus as well as butyrate-producing species, namely Gemmiger formicilis and Anaerobutyricum soehngenii, potentially influencing TNBC aggressiveness and clinical outcomes. Additionally, our functional analyses reveal the involvement of the TNBC microbiome in several pathways associated with chronic inflammation, increased cellular proliferation, invasion, and metastasis. This study uncovers novel microbial players in TNBC that could explain its aggressiveness and poor prognosis, and warrants further investigation into microbiome-driven interventions.

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揭示TNBC患者乳腺组织中新的微生物玩家：一个元分析的角度。

三阴性乳腺癌（TNBC）是最具侵袭性的乳腺癌（BC）亚型，占BC相关死亡人数的近40%。新出现的证据表明，乳房组织微生物群拥有独特的微生物群落；然而，TNBC特有的微生物群在很大程度上仍未被探索。本研究首次对TNBC组织微生物组进行了综合荟萃分析，整合了来自4个独立队列的200 BC样本的16S rRNA扩增子测序数据。我们的分析强调了氮螺旋菌属和产丁酸盐的物种（即formicilgemmiger和Anaerobutyricum soehngenii）的富集，可能会影响TNBC的侵袭性和临床结果。此外，我们的功能分析揭示了TNBC微生物组参与了与慢性炎症、细胞增殖增加、侵袭和转移相关的几种途径。这项研究揭示了TNBC中新的微生物参与者，可以解释其侵袭性和不良预后，并值得进一步研究微生物组驱动的干预措施。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.