Sex-specific association of novel complex inflammatory markers with colorectal polyps: mediating effects of triglyceride-glucose and non-high-density lipoprotein cholesterol.
Min Li, Yujing Wan, Na Wang, Ziyue Wei, Jieru Zhou, Wenjing Gui, Chunwu Zhang, Weihong Lin
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引用次数: 0
Abstract
Background: The CRP-albumin-lymphocyte (CALLY) index has potential clinical value as a novel marker integrating inflammatory, nutritional and immune status in the development of colorectal polyps. This study examined whether gender factors influence the association between CALLY and colorectal polyps; in addition to elucidating whether metabolic pathways mediate this relationship.
Methods: This is a cross-sectional study including 5409 adult health screening participants who completed colonoscopy. Logistic regression analysis, correlation analysis, linear regression analysis and restricted cubic spline modeling, and mediation analysis were employed to investigate the intricate associations between CALLY index, inflammatory biomarkers, metabolic factors and colorectal polyps.
Results: A total of 2201 subjects were diagnosed with colorectal polyps. Logistic regression analysis showed that higher CALLY index quartiles were inversely correlated with colorectal polyp prevalence (OR = 0.83,95% CI = 0.70-0.98, P = 0.025), and that this association was more pronounced in the female population (OR = 0.67,95% CI = 0.50-0.91, P = 0.011), while no significant association was observed in males (P > 0.05). Mediation analyses showed partial mediation of TyG (mediated effect: 15.14%, P < 0.01) and Non-HDL-C (mediated effect: 8.20%, P < 0.01) between CALLY index and colorectal polyps, whereas females showed stronger mediation of TyG (mediated effect: 15.49%, P = 0.020).
Conclusions: There were sex differences in the negative association of CALLY index with colorectal polyps, with a stronger association in women; the glucose metabolism (TyG) and lipid metabolism (Non-HDL-C) pathways partially mediated the association, and the mediating effect of TyG was more significant in women.
背景：crp -白蛋白淋巴细胞（CALLY）指数作为一种综合结肠直肠息肉发展过程中炎症、营养和免疫状况的新指标具有潜在的临床价值。本研究探讨性别因素是否影响CALLY与结直肠息肉之间的关系；除了阐明代谢途径是否介导这种关系。方法：这是一项横断面研究，包括5409名完成结肠镜检查的成人健康筛查参与者。采用Logistic回归分析、相关分析、线性回归分析、受限三次样条建模和中介分析等方法探讨CALLY指数、炎症生物标志物、代谢因子与结直肠息肉的复杂关系。结果：共2201名受试者被诊断为结直肠息肉。Logistic回归分析显示，CALLY指数高的四分位数与结直肠息肉患病率呈负相关（OR = 0.83,95% CI = 0.70-0.98, P = 0.025），且这种相关性在女性人群中更为明显（OR = 0.67,95% CI = 0.50-0.91, P = 0.011），而在男性人群中无显著相关性（P < 0.05）。结论：CALLY指数与结直肠息肉呈负相关存在性别差异，且在女性中相关性更强；糖代谢（TyG）和脂质代谢（Non-HDL-C）途径部分介导了该关联，且TyG的介导作用在女性中更为显著。
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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