Yali Xu, Mingdan Li, Chengde Su, Qianqian Zhu, Qian Liu, Ying Zhang, Xinyi Zhang, Qiuxiang Li, Huajun Wang, Ping Yang
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引用次数: 0
Abstract
Introduction: Cognitive frailty (CF), which typically precedes dementia and functional decline, serves as a more robust predictor of adverse health outcomes compared to physical frailty alone, representing a critical challenge in promoting healthy aging among older people living with HIV (PLWH) aged ≥ 50 years. This study aimed to investigate the prevalence of cognitive frailty and identify its associated factors among PLWH aged ≥ 50 years.
Methods: A convenience sample of 344 PLWH ≥ 50 years was recruited from a tertiary Grade A hospital in Zunyi, China. Physical frailty: evaluated via the Fatigue, Resistance, Ambulation, Illnesses, and Loss of Weight (FRAIL) Scale; Cognitive function: assessed via the Chinese version of the Montreal Cognitive Assessment (MoCA). Participants were divided into the cognitive frailty group (FRAIL score ≥ 3 and MoCA score < 26), the non-cognitive frailty group. Binary logistic regression analysis was conducted with SPSS 29.0 to identify factors associated with CF.
Results: The prevalence of CF among the 344 PLWH aged ≥ 50 years was 37.5%. Regression analysis revealed that the following associated factors (p < 0.05) were independent risk factors for CF in PLWH aged ≥ 50 years: age, education level, weekly frequency of physical activity ≤ 2 sessions, depression, sleep disorders, and EFV-containing regimens.
Conclusions: Cognitive frailty is highly prevalent among PLWH aged ≥ 50 years. Early screening and comprehensive healthcare interventions targeting modifiable risk factors are crucial for delaying or reversing CF progression in this population.
期刊介绍：
Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.
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