Spike-timing-dependent plasticity offers delay-gated oscillatory potentiation for autaptic weights.

IF 3 3区医学 Q2 NEUROSCIENCES

Frontiers in Neural Circuits Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI:10.3389/fncir.2025.1646317

Risa Onda, Mihoko Ishida, Kouhei Hattori, Hideaki Yamamoto, Takashi Tanii

引用次数: 0

Abstract

Neuronal networks in animal brains are considered to realize specific filter functions through the precise configuration of synaptic weights, which are autonomously regulated without external supervision. In this study, we employ a single Hodgkin-Huxley-type neuron with autapses as a minimum model to computationally investigate how spike-timing-dependent plasticity (STDP) adjusts synaptic weights through recurrent feedback. The results show that the weights undergo oscillatory potentiation or depression with respect to autaptic delay and high-frequency stimulation. Our findings suggest that the STDP-mediated modulation of autaptic weights, governed by autaptic delay and input frequency, may serve as a mechanism for promoting network-level synchronization in neural systems if the network contains neurons with autapses.

Abstract Image

查看原文本刊更多论文

峰值时间依赖的可塑性为自适应权重提供了延迟门控振荡增强。

动物大脑中的神经元网络被认为是通过突触权重的精确配置来实现特定的过滤功能，突触权重是在没有外界监督的情况下自主调节的。在本研究中，我们采用单个霍奇金-赫胥黎型神经元作为最小模型，计算研究spike- time -dependent plasticity （STDP）如何通过循环反馈调节突触权重。结果表明，相对于自适应延迟和高频刺激，权值发生振荡增强或抑制。我们的研究结果表明，stdp介导的自适应权调制，受自适应延迟和输入频率的控制，可能是促进神经系统中网络级同步的机制，如果网络中包含具有autapses的神经元。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Neural Circuits NEUROSCIENCES-

CiteScore

6.00

自引率

5.70%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.