Strategic Targets in Acne, Update 2025: The Microcomedone Is Not Just a Plug, It Is an Egg.

IF 2.7 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2025-09-09 DOI:10.1159/000547515

Bénédicte Oulès, Jean Hilaire Saurat

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引用次数: 0

Abstract

Background: Maintaining homeostasis in the upper pilosebaceous unit in acne-prone skin has emerged as the primary goal for effective and long-term acne management.

Summary: In this review, we describe advances in acne research that have helped redefine the strategic targets for new topical acne treatments, providing the basis for new therapeutic strategies that may allow this goal to be achieved.

Key messages: First, we describe the results of studies analyzing apparently uninvolved skin from individuals with acne, using sequential skin surface biopsies. These studies led to the identification of subclinical lesions, referred to as microcomedones, as the root of all subsequent acne lesions, and thus clinically non-lesional acne skin as the strategic target for new acne therapies. We then describe the concept of the comedo switch, in which exposure of progenitor cells in the pilosebaceous unit to comedogenic factors in acne-prone skin leads to the formation of microcomedones. Previously considered as an "inert plug", the microcomedone rather appears to be "an egg" that can grow into acne lesions.

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痤疮的战略目标，更新2025：微型粉刺不只是一个插头，它是一个鸡蛋。

背景：维持痤疮易发皮肤上毛囊皮脂腺单位的稳态已成为有效和长期痤疮管理的主要目标。摘要：在这篇综述中，我们描述了痤疮研究的进展，这些进展有助于重新定义新的局部痤疮治疗的战略目标，为新的治疗策略提供了基础，可能使这一目标得以实现。关键信息：首先，我们描述了使用连续皮肤表面活检分析痤疮个体明显未涉及皮肤的研究结果。这些研究确定了亚临床病变，即微粉刺，是所有后续痤疮病变的根源，因此临床非病变性痤疮皮肤作为新的痤疮治疗的战略目标。然后我们描述了粉刺开关的概念，其中毛囊皮脂腺单位的祖细胞暴露于痤疮易发皮肤中的粉刺形成因素导致微粉刺的形成。以前被认为是“惰性堵塞”的微粉刺看起来更像是“一个鸡蛋”，可以生长成痤疮病灶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.