Toluquinol modulates NR1D1 and circadian rhythm in lung cancer cells: Implications for circadian medicine.

IF 1.7 4区 医学 Q2 BIOLOGY
Nidhi Nagariya, Vihas Vasu, Kaushalkumar Chaudhari, Aparna Golani, Jyoti Vihas Thaikoottathil, Hetal Roy
{"title":"Toluquinol modulates <i>NR1D1</i> and circadian rhythm in lung cancer cells: Implications for circadian medicine.","authors":"Nidhi Nagariya, Vihas Vasu, Kaushalkumar Chaudhari, Aparna Golani, Jyoti Vihas Thaikoottathil, Hetal Roy","doi":"10.1080/07420528.2025.2556834","DOIUrl":null,"url":null,"abstract":"<p><p>Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, <i>NR1D1</i> plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of <i>NR1D1</i> has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on <i>NR1D1</i> gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.</p>","PeriodicalId":10294,"journal":{"name":"Chronobiology International","volume":" ","pages":"1-23"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07420528.2025.2556834","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Lung cancer remains one of the most fatal cancers, with cigarette smoke (CS) exposure being a major risk factor due to its role in triggering oxidative stress. Disruption of circadian rhythms, increasingly common in modern lifestyles, has also been linked to cancer progression. Targeting both oxidative imbalance and circadian disruption may offer a more effective therapeutic approach. Toluquinol (TQ), a compound derived from marine fungi, has shown promising anti-tumor activity and potential relevance in circadian-based cancer strategies. The current study investigated the role of TQ as a potential circadian medicine in modulating the dysregulated circadian-regulatory gene expression in the CS-exposed NCI-H23 lung adenocarcinoma cell line. Among the core circadian regulatory genes, NR1D1 plays a crucial role as a transcriptional repressor, involved in maintaining the circadian rhythm, regulating redox homeostasis, and modulating inflammation. Dysregulation of NR1D1 has been linked to cancer progression and poor prognosis in lung cancer. This study offers valuable insights into the impact of CS on NR1D1 gene regulation and its role in lung cancer development, which is mediated through disrupted redox balance and inflammation, while highlighting the potential therapeutic role of TQ in mitigating this process.

甲苯醌调节肺癌细胞的NR1D1和昼夜节律:对昼夜节律医学的影响。
肺癌仍然是最致命的癌症之一,香烟烟雾(CS)暴露是一个主要的危险因素,因为它在触发氧化应激中的作用。在现代生活方式中越来越普遍的昼夜节律紊乱也与癌症的发展有关。同时针对氧化失衡和昼夜节律紊乱可能提供更有效的治疗方法。甲苯喹诺(TQ)是一种从海洋真菌中提取的化合物,具有良好的抗肿瘤活性,并可能与基于昼夜节律的癌症策略相关。目前的研究调查了TQ作为一种潜在的昼夜节律药物,在cs暴露的NCI-H23肺腺癌细胞系中调节昼夜节律调节基因表达失调的作用。在核心的昼夜节律调节基因中,NR1D1作为转录抑制因子发挥着至关重要的作用,参与维持昼夜节律、调节氧化还原稳态和调节炎症。NR1D1的失调与肺癌的癌症进展和不良预后有关。本研究为CS对NR1D1基因调控的影响及其在肺癌发展中的作用提供了有价值的见解,这是通过破坏氧化还原平衡和炎症介导的,同时强调了TQ在缓解这一过程中的潜在治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Chronobiology International
Chronobiology International 生物-生理学
CiteScore
5.60
自引率
7.10%
发文量
110
审稿时长
1 months
期刊介绍: Chronobiology International is the journal of biological and medical rhythm research. It is a transdisciplinary journal focusing on biological rhythm phenomena of all life forms. The journal publishes groundbreaking articles plus authoritative review papers, short communications of work in progress, case studies, and letters to the editor, for example, on genetic and molecular mechanisms of insect, animal and human biological timekeeping, including melatonin and pineal gland rhythms. It also publishes applied topics, for example, shiftwork, chronotypes, and associated personality traits; chronobiology and chronotherapy of sleep, cardiovascular, pulmonary, psychiatric, and other medical conditions. Articles in the journal pertain to basic and applied chronobiology, and to methods, statistics, and instrumentation for biological rhythm study. Read More: http://informahealthcare.com/page/cbi/Description
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信