Ru-Catalyzed Asymmetric Transfer Hydrogenation of α-iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α-Aminophosphonates.

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-09-09 DOI:10.1002/chem.202502405

Pierre Plouard, Laura Borrel, Pierre-Olivier Butin, Paul Muller, Rémi Cherpitel, Séverine Loiseau, Ludovic Clarion, David Virieux, Tahar Ayad

引用次数: 0

Abstract

A novel Ru-catalyzed asymmetric transfer hydrogenation (ATH) strategy has been developed for the efficient synthesis of valuable chiral α-aminophosphonates from readily available α-iminophosphonates. This method enables the conversion of both acyclic and cyclic substrates in high yields (up to 97%) and excellent enantioselectivities (up to >99:1), providing a practical entry to phosphorus-containing chiral amines. Notably, this is the first reported application of ATH to α-iminophosphonates, offering a robust and operationally convenient alternative to conventional asymmetric hydrogenation (AH) approaches.

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钌催化α-亚氨基膦酸盐的不对称转移加氢：一种有价手性α-氨基膦酸盐合成新方法。

研究了一种钌催化的不对称转移加氢（ATH）方法，该方法可以从易得的α-亚氨基膦酸盐中高效合成有价手性α-氨基膦酸盐。该方法能够以高收率（高达97%）和优异的对映选择性（高达bbb99:1）转化无环和环底物，为含磷手性胺提供了一个实用的入口。值得注意的是，这是首次报道将ATH应用于α-亚氨基膦酸盐，为传统的不对称氢化（AH）方法提供了一种强大且操作方便的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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