Palladium-Catalyzed Coupling of Aryl Iodides with Sulfinamide Reagents for the Construction of Sulfinamides.

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-09-10 DOI:10.1002/chem.202502496

Rutian Sun, Daming Zeng, Ming Wang, Xuefeng Jiang

引用次数: 0

Abstract

A novel sulfinamide reagent was developed that enables the one-step installation of sulfinamides through palladium-catalyzed coupling with aryl iodides. This method offers distinct advantages, including the use of readily available starting materials and broad substrate compatibility. Moreover, the strategy was successfully extended to the synthesis of complex functional molecules. Mechanistic investigations reveal that the key intermediate undergoes base-promoted retro-Michael addition to afford the target product.

查看原文本刊更多论文

钯催化芳基碘化物与亚砜酰胺试剂偶联制备亚砜酰胺。

开发了一种新型亚砜胺试剂，通过钯催化与芳基碘化物的偶联，实现了亚砜胺的一步安装。这种方法具有明显的优点，包括使用现成的起始材料和广泛的衬底兼容性。此外，该策略已成功地扩展到复杂功能分子的合成。机制研究表明，关键中间体经过基础促进的复古迈克尔添加，以提供目标产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.