Synthesis and Chemo-Sensitizing Properties of New Monoterpene-Containing Inhibitors of Histone Deacetylases: Hydroxamic Acids and Mercaptoacetamides

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2025-09-10 DOI:10.1134/S1070363225603813

Yu. R. Aleksandrova, A. A. Munkuev, I. A. Shagina, E. V. Suslov, K. P. Volcho, N. F. Salakhutdinov, M. E. Neganova

引用次数: 0

Abstract

A number of histone deacetylase inhibitors (HDACi) containing an adamantane backbone in the CAP group, as well as hydroxamate or mercaptoacetamide functions as zinc-binding fragments connected via a monoterpene linker, were synthesized. It was found that, being HDAC inhibitors, the synthesized compounds significantly enhance the cytotoxic activity of cisplatin against human cervical carcinoma cells HeLa.

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新的组蛋白去乙酰化酶单萜抑制剂的合成及其化学增敏性能：羟肟酸和巯基乙酰胺

合成了许多组蛋白去乙酰化酶抑制剂（HDACi），其中含有CAP基团中的金刚烷骨架，以及羟酸盐或巯基乙酰胺作为锌结合片段，通过单萜烯连接。结果表明，所合成的化合物均为HDAC抑制剂，可显著增强顺铂对人宫颈癌HeLa细胞的细胞毒活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.