Novel approach to monitor local tissue ischemia associated with pressure ulcers using an optical fibre carbon dioxide sensor†

IF 4.1 Q2 CHEMISTRY, ANALYTICAL
Nadia Afroze, Serhiy Korposh, Ricardo Correia, Peter R. Worsley, Barrie R. Hayes-Gill, Seung-Woo Lee and Stephen P. Morgan
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Abstract

In this paper, we describe the development of a novel approach to monitor local tissue ischemia associated with pressure ulcer using an optical fibre carbon dioxide sensor. Carbon dioxide (CO2) is a potential biomarker for local tissue ischemia associated with pressure ulcer (PU) formation. Skin CO2 measurement during loading could provide an earlier indicator for pressure induced tissue damage. This study presents a reflection mode optical fibre CO2 sensor (OFCS) that was fabricated and evaluated for measuring skin CO2 during mechanical loading. The optical fibre tip was coated with organically modified silica gel (ormosil) film (thickness 7.23 ± 0.52 μm) containing thymol blue using a dip coating process. Thymol blue has an absorption peak at a wavelength of ~600 nm with an amplitude proportional to CO2 concentration. The OFCS had a typical response time of approximately 60 seconds and a recovery time of 400 seconds for a 0–5.5% CO2 range. OFCSs were tested on the human skin of six healthy volunteers with corresponding CO2 peak values ranging from 145 ppm to 429 ppm with a percent error range of 6–32.2%. The increase in CO2 emitted from the skin during loading offers future promise for alerting the early stage of PU formation.

Abstract Image

使用光纤二氧化碳传感器†监测与压疮相关的局部组织缺血的新方法
在本文中,我们描述了一种使用光纤二氧化碳传感器监测与压疮相关的局部组织缺血的新方法的发展。二氧化碳(CO2)是与压疮(PU)形成相关的局部组织缺血的潜在生物标志物。加载过程中皮肤二氧化碳的测量可以提供压力诱导的组织损伤的早期指标。本研究提出了一种反射模式光纤二氧化碳传感器(OFCS),该传感器用于测量机械加载过程中的皮肤二氧化碳。采用浸涂法在光纤尖端涂覆一层厚度为7.23±0.52 μm的百里香酚蓝有机改性硅胶(ormosil)薄膜。百里香酚蓝在~600 nm波长处有一个吸收峰,其振幅与CO2浓度成正比。在0-5.5% CO2范围内,OFCS的典型响应时间约为60秒,恢复时间为400秒。在6名健康志愿者的皮肤上测试了ofcs,相应的CO2峰值范围为145 ppm ~ 429 ppm,误差范围为6-32.2%。在加载过程中,从表皮排放的二氧化碳的增加为预警PU形成的早期阶段提供了未来的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.30
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0.00%
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