Holographic hydrogel bandage sensor for continual monitoring of wound healing†

IF 4.1 Q2 CHEMISTRY, ANALYTICAL
Yihan Zhang, Yubing Hu, Zhenkang Zhu, Yunuen Montelongo, Yanting Liu, Shihabuddeen Waqar, Yoon Soo Park, Leon CZ Chan, Nan Jiang and Ali K. Yetisen
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Abstract

Chronic wounds pose serious health and economic challenges. A low calcium (Ca2+) ion concentration during the early stage often indicates infections. Holographic hydrogel sensors offer label-free sensing platforms, providing real-time and continuous detections of analytes upon diffractive wavelength changes detectable by the naked eye or spectrophotometers, improving the Ca2+ ion concentration quantification accessibility. Herein, we present a holographic Ca2+ ion bandage sensor using carboxylate-containing hydrogels on polydimethylsiloxane (PDMS) substrates for real-time wound-healing assessment through smartphone readout. Simulations are conducted to investigate the effects of mechanical strength on sensitivity. The holographic Ca2+ ion sensor replays blueshifts of 35 nm (hue value change of 7) with 0–4 mmol L−1 Ca2+ ions, changing colors from dark red to red within 7 minutes. It can accurately and stably (over 24 hours) measure Ca2+ ions when bent. The stiffness of PDMS was tuned to balance comfort and sensitivity. In point-of-care settings, holographic bandage sensors, comprising the holographic hydrogel sensor, a backing layer, and a dark cotton layer, can continuously monitor Ca2+ ions over 10 hours via a smartphone application using hue values. A guiding square in the application assists users in capturing pictures within the inherently narrow viewing angle range of 20–33°. This holographic Ca2+ ion bandage sensor facilitates personalized wound assessment through colorimetric interrogation via smartphone readout.

Abstract Image

全息水凝胶绷带传感器持续监测伤口愈合†
慢性伤口构成严重的健康和经济挑战。早期低钙(Ca2+)离子浓度通常表明感染。全息水凝胶传感器提供无标签传感平台,在肉眼或分光光度计可检测到的衍射波长变化时,提供实时和连续的分析物检测,提高了Ca2+离子浓度定量的可及性。在这里,我们提出了一种全息Ca2+离子绷带传感器,使用含羧酸的水凝胶在聚二甲基硅氧烷(PDMS)底物上,通过智能手机读数实时评估伤口愈合。通过仿真研究了机械强度对灵敏度的影响。全息Ca2+离子传感器在0-4 mmol L−1 Ca2+离子下重放35 nm(色调值变化7)的蓝移,在7分钟内从暗红色变为红色。在弯曲状态下,能准确、稳定(24小时以上)测量Ca2+离子。调整了PDMS的刚度以平衡舒适性和灵敏度。在护理点设置中,全息绷带传感器,包括全息水凝胶传感器,衬底层和深色棉花层,可以通过智能手机应用程序使用色调值连续监测Ca2+离子超过10小时。应用程序中的引导方框帮助用户在固有的20-33°狭窄视角范围内捕获图像。这种全息Ca2+离子绷带传感器通过智能手机读出的比色审讯促进个性化伤口评估。
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来源期刊
CiteScore
2.30
自引率
0.00%
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