Copper-incorporated hydrogels loaded with curcumin microspheres for the repair of bone defects

IF 10.2 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Wencan Lu , Weida Zhuang , Wenhua Li , Hongxun Sang
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引用次数: 0

Abstract

Addressing bone defects continues to be an exceedingly difficult challenge owing to local immune dysregulation, vascular injury, and disorders of osteogenesis. No entirely satisfactory resolution has been achieved. In this work, through loading curcumin/poly (lactic-co-glycolic acid) microspheres constructed via a double emulsion technique, a copper-incorporated carboxymethyl chitosan/sodium alginate hydrogel (CA-Cur@Cu hydrogel) was developed. The CA-Cur@Cu hydrogels can sustain the release of curcumin for a long time. This sustained release demonstrates effective antioxidant and anti-inflammatory properties, inducing M2 polarization of macrophages and enhancing the bone immune microenvironment. Furthermore, Cu2+ released from the CA-Cur@Cu hydrogels induces angiogenesis and osteogenesis, which synergize with anti-inflammatory properties of curcumin to accelerate the repair of bone defects. Additionally, the CA-Cur@Cu hydrogels exhibit remarkable antibacterial activity, effectively inhibiting clinical bacterial infections. Overall, this study successfully constructed a multifunctional hydrogel integrating antioxidant, anti-inflammatory, pro-angiogenic, and osteogenic properties, providing a new perspective and potential solution for the treatment of bone defects.

Abstract Image

含铜的姜黄素微球水凝胶用于骨缺损修复
由于局部免疫失调、血管损伤和成骨障碍,解决骨缺损仍然是一个极其困难的挑战。没有达成完全令人满意的解决办法。本研究通过双乳法制备姜黄素/聚乳酸-羟基乙酸微球,制备了含铜羧甲基壳聚糖/海藻酸钠水凝胶(CA-Cur@Cu)。CA-Cur@Cu水凝胶能长时间维持姜黄素的释放。该缓释具有有效的抗氧化和抗炎特性,诱导巨噬细胞M2极化,增强骨免疫微环境。此外,CA-Cur@Cu水凝胶释放的Cu2+诱导血管生成和成骨,这与姜黄素的抗炎特性协同作用,加速骨缺损的修复。此外,CA-Cur@Cu水凝胶具有显著的抗菌活性,可有效抑制临床细菌感染。总之,本研究成功构建了一种集抗氧化、抗炎、促血管生成和成骨为一体的多功能水凝胶,为骨缺损的治疗提供了新的视角和潜在的解决方案。
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来源期刊
CiteScore
8.30
自引率
4.90%
发文量
303
审稿时长
30 days
期刊介绍: Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).
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