A cohort study of nutritional secondary hyperparathyroidism in horses in Hawaiʻi

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-09-04 DOI:10.1016/j.rvsc.2025.105868

Laszlo M. Hunyadi , Emily A. Sundman

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引用次数: 0

Abstract

Equine nutritional secondary hyperparathyroidism (NSHP, Bighead Disease) is a consequence of diets with abnormal calcium: phosphorus ratios. With the widespread availability of fortified feeds and legume forage, the disease has largely disappeared. The Hawaiian Islands are unique in that legume forage is largely unavailable and pastures have high oxalate concentrations. This was a cohort study that included seventeen adult horses imported from the continental US to the Waiki'i region, Hawaiʻi that grazed on kikuyu grass pastures. Plasma ionized calcium and parathyroid hormone concentrations at baseline and after eight months were evaluated. Calcium supplementation was provided via gastroprotectant formulations with Group 1 (eight horses) receiving supplement 1 and Group 2 (five horses) receiving supplement 2. 8/17 horses were normal and 9/17 horses were diagnosed with NSHP. In Group 1, 1 NSHP horse resolved, 4 NSHP horses remained affected, 2 non-NSHP horses remained unaffected, and 1 non-NSHP horse developed disease. In Group 2, 2 NSHP horses resolved, 1 NSHP horse remained affected, and 2 non-NSHP horses remained unaffected. A statistically significant difference between treatment cohorts was found in post-treatment ionized calcium (p-value =0.0063) and parathyroid hormone (p-value =0.0236) concentrations. The results of this study demonstrate that NSHP remains a common disease in regions without consistent access to fortified feeds and with high oxalate grasses leading to oxalate toxicosis. Calcium supplementation may be effective in some horses, but continued monitoring is required.

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夏威夷马营养继发性甲状旁腺功能亢进的队列研究

马营养性继发性甲状旁腺功能亢进（NSHP, high head Disease）是饮食中钙磷比例异常的结果。随着强化饲料和豆类饲料的广泛使用，这种疾病已基本消失。夏威夷群岛的独特之处在于豆科牧草在很大程度上是不可获得的，牧场草酸盐浓度很高。这是一项队列研究，包括17匹从美国大陆进口到夏威夷怀基伊地区的成年马，这些马在基库尤人的牧场上吃草。血浆电离钙和甲状旁腺激素浓度在基线和8个月后进行评估。通过胃保护剂配方补充钙，组1（8匹马）接受补充1，组2（5匹马）接受补充2。8/17匹马正常，9/17匹马被诊断为NSHP。在第1组，1匹NSHP马痊愈，4匹NSHP马仍受影响，2匹非NSHP马未受影响，1匹非NSHP马发病。在第2组中，2匹NSHP马消退，1匹NSHP马仍受影响，2匹非NSHP马未受影响。治疗组间治疗后离子钙（p值=0.0063）和甲状旁腺激素（p值=0.0236）浓度差异有统计学意义。本研究的结果表明，在没有持续获得强化饲料和草酸含量高的草导致草酸中毒的地区，NSHP仍然是一种常见疾病。补钙对某些马可能有效，但需要继续监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.