Hemostatic evaluation in dogs with lymphoma – Systematic review

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2025-09-03 DOI:10.1016/j.rvsc.2025.105885

Tatiana Geraissate Gorenstein , Pedro Antônio Bronhara Pimentel , Fabíola de Oliveira Paes Leme , Rita Carolina Figueiredo Duarte , Rodrigo dos Santos Horta

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引用次数: 0

Abstract

Background

Lymphoma is characterized by clonal proliferation of malignant lymphocytes and it is the most common hematopoietic cancer in dogs. Affected patients may exhibit increased thrombotic risk due to cancer-associated dysregulation of hemostatic pathways, including tissue factor overexpression in tumor stroma, activation of plasminogen inhibitors and coagulation proteases and systemic inflammation.

Objectives

This study aimed to evaluate the impact of lymphoma on hemostatic function in canine patients.

Methods

This review was elaborated in accordance with the Cochrane Handbook for Systematic Reviews (v6.3, 2022). Eligibility criteria encompassed original studies, published in databases, 1960–2024, assessing hemostatic variables in canine patients with confirmed diagnosis of lymphoma. Analyzed parameters included: platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, antithrombin (AT), fibrinogen degradation products (FDPs), D-dimer concentration, platelet aggregation and viscoelastic testing.

Results

Dogs with lymphoma demonstrated platelet counts, aPTT, and AT activity within reference intervals. Increased viscoelasticity and elevated FDPs/D-dimer levels, indicating hypercoagulability.

Conclusions

Canine lymphoma is linked to an increased thrombotic risk, reflected by hypercoagulable profiles and elevated FDPs and D-dimers, likely driven by tumor-associated procoagulant activity and inflammation. Platelet dynamics are variable and influenced by chemotherapy, and comparisons are limited by lymphoma heterogeneity and study variability. Future research should standardize lymphoma classification, monitor hemostatic changes longitudinally, and correlate biomarkers with clinical outcomes to improve risk stratification and therapy.

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犬淋巴瘤的止血评价-系统综述

淋巴瘤以恶性淋巴细胞的克隆性增殖为特征，是犬中最常见的造血肿瘤。由于癌症相关的止血途径失调，包括肿瘤基质组织因子的过度表达、纤溶酶原抑制剂和凝血蛋白酶的激活以及全身性炎症，受影响的患者可能表现出血栓形成风险增加。目的探讨淋巴瘤对犬止血功能的影响。方法本综述按照Cochrane系统综述手册（v6.3, 2022）进行阐述。入选标准包括1960-2024年发表在数据库中的原始研究，评估确诊为淋巴瘤的犬患者的止血变量。分析参数包括：血小板计数、凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、纤维蛋白原、抗凝血酶（AT）、纤维蛋白原降解产物（FDPs）、d -二聚体浓度、血小板聚集和粘弹性试验。结果淋巴瘤犬的血小板计数、aPTT和AT活性均在参考区间内。粘弹性增加，fdp / d -二聚体水平升高，表明高凝性。结论：扫描性淋巴瘤与血栓形成风险增加有关，反映在高凝特征和fdp和d -二聚体升高上，可能是由肿瘤相关的促凝活性和炎症驱动的。血小板动力学是可变的，受化疗的影响，比较受淋巴瘤异质性和研究可变性的限制。未来的研究应标准化淋巴瘤分类，纵向监测止血变化，并将生物标志物与临床结果相关联，以改善风险分层和治疗。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.