Potential application of nanotechnology in Type-3 diabetes: Bridging insulin resistance and neurodegeneration

Nano Trends Pub Date : 2025-09-01 DOI:10.1016/j.nwnano.2025.100144

Adrija Ghosh , Sresha Sarkar , Debashmita Mandal , Jonathan Tersur Orasugh , Suprakas Sinha Ray , Dipankar Chattopadhyay

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Abstract

This review explores the emerging concept of Type-3 diabetes (T3D), an unconventional classification linking insulin resistance with neurodegenerative processes. It explores the intricate molecular mechanisms underlying this association and highlights the importance of early diagnosis for effective intervention. The tale emphasizes the central role of nanomaterials (NMTs) in transforming diagnostic and therapeutic strategies for T3D. Nanoparticles (NPs), nanosensors, and quantum dots (QDs) have emerged as effective tools enabling the precise detection of relevant biomarkers and facilitating early disease identification. Additionally, the multifunctionality of NMTs opens avenues for targeted drug delivery (DD) and imaging modalities, promising a holistic approach to treatment. The integration of nanotechnology enhances diagnostic accuracy and presents innovative therapeutic modalities, ushering in T3D management, which is entering a new era. This comprehensive exploration underscores the potential of NMTs in reshaping our understanding and clinical approaches to this intricate intersection of metabolic and neurodegenerative disorders.

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纳米技术在3型糖尿病中的潜在应用：桥接胰岛素抵抗和神经变性

这篇综述探讨了3型糖尿病（T3D）的新兴概念，这是一种将胰岛素抵抗与神经退行性过程联系起来的非常规分类。它探讨了这种关联背后复杂的分子机制，并强调了早期诊断对有效干预的重要性。这个故事强调了纳米材料（NMTs）在改变T3D诊断和治疗策略中的核心作用。纳米粒子（NPs）、纳米传感器和量子点（QDs）已经成为精确检测相关生物标志物和促进早期疾病识别的有效工具。此外，nmt的多功能性为靶向给药（DD）和成像模式开辟了道路，有望采用整体治疗方法。纳米技术的整合提高了诊断的准确性，并提出了创新的治疗方式，迎来了T3D管理，这正在进入一个新的时代。这项全面的探索强调了nmt在重塑我们对代谢和神经退行性疾病这一复杂交集的理解和临床方法方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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