Adjunctive Doxazosin before Ureterolithotripsy to Improve Successful Access Rate: A Retrospective Analysis.

IF 0.9 4区医学 Q4 UROLOGY & NEPHROLOGY

Archivos Espanoles De Urologia Pub Date : 2025-08-01 DOI:10.56434/j.arch.esp.urol.20257807.118

Shang Xu, Xinning Wang, Bin Li, Yuxia Lin, Zhilong Liu, Wei Jiao

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引用次数: 0

Abstract

Background: Ureteroscopic lithotripsy using a semi-rigid ureteroscope is the standard treatment for urinary stones. Doxazosin-an alpha-1 adrenergic receptor blocker-relaxes ureteral smooth muscles, reducing peristalsis and contraction frequency. This study aimed to evaluate the efficacy and safety of adjunctive doxazosin before semi-rigid ureteroscopy and retrograde intrarenal surgery (RIRS) for urinary stones.

Methods: We analyzed the data of patients who underwent semi-rigid ureteroscopy and RIRS between January 1, 2022 and December 31, 2022. The patients were divided into four groups: Patients who underwent semi-rigid ureteroscopy with or without doxazosin preoperatively and patients who underwent RIRS with or without doxazosin preoperatively. We assessed the patient's age and sex; Stone laterality, location, and maximum diameter; Successful access rate; And surgical complications. Pearson's chi-square, Fisher's exact, and Student's t-tests were used for the statistical analyses.

Results: The final analysis included 266 patients. Patient's age and sex and stone laterality, location, and maximal diameter were similar between the groups. In the semi-rigid ureteroscopic lithotripsy group, the successful access rate was higher in patients who received doxazosin (95%) compared with those who did not (79.69%) (p = 0.023). In the RIRS group, the successful access rate was higher in patients who received doxazosin (84.09%) compared with those who did not (57.41%) (p = 0.040). In the RIRS group, the duration of postoperative double-J stent placement in patients who received doxazosin was significantly shorter than that in those who did not (p = 0.010). Notably, no serious drug-related adverse events were observed.

Conclusions: Doxazosin can be safely and effectively used before semi-rigid and flexible ureteroscopy.

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输尿管碎石术前辅助多沙唑嗪提高输尿管碎石成功率的回顾性分析。

背景：采用半刚性输尿管镜进行输尿管镜碎石是治疗尿路结石的标准方法。多沙唑辛- α -1肾上腺素能受体阻滞剂-放松输尿管平滑肌，减少蠕动和收缩频率。本研究旨在评价半刚性输尿管镜和逆行肾内手术（RIRS）前辅助多沙唑嗪治疗尿路结石的疗效和安全性。方法：我们分析2022年1月1日至2022年12月31日期间接受半刚性输尿管镜检查和RIRS的患者资料。患者分为四组：术前加或不加doxazosin进行半刚性输尿管镜检查的患者和术前加或不加doxazosin进行RIRS的患者。我们评估了患者的年龄和性别；石材横向、位置、最大直径；成功访问率；还有手术并发症。使用Pearson卡方检验、Fisher精确检验和Student t检验进行统计分析。结果：最终纳入266例患者。患者的年龄、性别、结石的侧边、位置和最大直径在两组之间相似。在半刚性输尿管镜碎石组中，给予doxazosin治疗的成功率（95%）高于未给予doxazosin治疗的成功率（79.69%）（p = 0.023）。在RIRS组中，接受doxazosin治疗的患者获得成功率（84.09%）高于未接受doxazosin治疗的患者（57.41%）（p = 0.040）。在RIRS组中，接受doxazosin治疗的患者术后双j型支架放置时间明显短于未接受doxazosin治疗的患者（p = 0.010）。值得注意的是，没有观察到严重的药物相关不良事件。结论：多沙唑嗪可安全有效地应用于半刚性和柔性输尿管镜检查前。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archivos Espanoles De Urologia UROLOGY & NEPHROLOGY-

CiteScore

0.90

自引率

0.00%

发文量

111

期刊介绍： Archivos Españoles de Urología published since 1944, is an international peer review, susbscription Journal on Urology with original and review articles on different subjets in Urology: oncology, endourology, laparoscopic, andrology, lithiasis, pediatrics , urodynamics,... Case Report are also admitted.