The role of intraoperative flow cytometry on intracranial tumor surgery : a scoping review.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Neurosurgical Review Pub Date : 2025-09-09 DOI:10.1007/s10143-025-03789-3

Eleni Romeo, Georgios Markopoulos, Spyridon Voulgaris, George Vartholomatos, George A Alexiou

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引用次数: 0

Abstract

Background: The aim of this review is to present the role of intraoperative flow cytometry (IFC) in the intracranial tumor surgery. This scoping review aims to summarize current evidence on the intraoperative use of IFC in patients with intracranial tumors.

Methods: A comprehensive literature search was conducted in the Medline, Cochrane and Scopus databases up to January 21, 2025. Data extraction was carried out following the use of preset inclusion and exclusion criteria.

Results: A total of 14 studies were analyzed in this review, involving 1.043 patients with intracranial tumors to assess the utility of IFC in the rapid diagnosis of these tumors. The studies evaluated IFC for grading gliomas and meningiomas, distinguishing tumor margins, determining tumor prognosis, and its application in pediatric tumors, metastases, and primary central nervous system lymphomas. The most promising applications of IFC are in glioma and meningioma grading, as well as in identifying glioma margins. IFC appears to be a valuable intraoperative tool for intracranial tumor classification, providing rapid results within minutes.

Conclusion: IFC shows potential as a real-time, intraoperative tool for brain tumor classification and surgical guidance. Nevertheless, studies in this field are limited, and further research with more robust data is needed to establish specific cut-off values that will enable reliable conclusions.

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术中流式细胞术在颅内肿瘤手术中的作用：范围综述。

背景：本综述的目的是介绍术中流式细胞术（IFC）在颅内肿瘤手术中的作用。本综述旨在总结目前颅内肿瘤患者术中使用IFC的证据。方法：在Medline、Cochrane和Scopus数据库中检索截至2025年1月21日的文献。按照预设的纳入和排除标准进行数据提取。结果：本综述共分析了14项研究，涉及1.043例颅内肿瘤患者，以评估IFC在这些肿瘤快速诊断中的应用。这些研究评估了IFC在胶质瘤和脑膜瘤分级、区分肿瘤边缘、确定肿瘤预后方面的应用，以及IFC在儿童肿瘤、转移瘤和原发性中枢神经系统淋巴瘤中的应用。IFC最有前途的应用是胶质瘤和脑膜瘤分级，以及胶质瘤边缘的识别。IFC似乎是一种有价值的术中颅内肿瘤分类工具，可在几分钟内提供快速结果。结论：IFC具有作为脑肿瘤实时、术中分类和手术指导工具的潜力。然而，这一领域的研究是有限的，需要用更可靠的数据进行进一步的研究，以确定能够得出可靠结论的具体临界值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurosurgical Review 医学-临床神经学

CiteScore

5.60

自引率

7.10%

发文量

191

审稿时长

6-12 weeks

期刊介绍： The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.