Factors and Disease-Specific Outcomes Associated With Treatment Delays in Osteosarcoma: A Population-Based Retrospective Cohort Study

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-09-09 DOI:10.1002/jso.70087

Kate S. Woods, Ryan T. Kauper, Anisha Kohli, Mitchell A. Taylor, Alex Gavia, Peter Silberstein

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Abstract

Introduction

Time to initiation of therapy in oncological care is an influential factor in disease progression and survival outcomes in many cancer types. We aim to identify factors associated with delayed time to treatment (TTT) in high-grade osteosarcoma and its relationship to disease-specific survival (DSS).

Methods

The SEER database was queried for biopsy-confirmed cases of high-grade osteosarcoma between 2000 and 2021 using ICD-O-3 histology codes 9180/3–9194/3 and primary site codes C40.0–41.9. χ², Kaplan–Meier with log-rank testing, and stepwise multivariable logistic regression were completed using SPSS, with significance set to p < 0.05.

Results

Kaplan–Meier analysis demonstrated significantly reduced 5- and 10-year DSS in patients with TTT over 1 month (p < 0.001). Multivariable analysis identified advanced age groups and tumors of the cranium (aOR 2.48; 95% CI 1.96–3.13), thorax (aOR 1.72; 95% CI 1.13–2.61), and pelvis (aOR 1.71; 95% CI 1.31–2.23) as factors associated with TTT delays over 1 month. Black race and Hispanic ethnicity were also significantly associated with treatment delays in subset analysis of patients < 40 years (aOR 1.74; 95% CI 1.27–2.39 and aOR 1.31; 95% CI 1.01–1.70).

Conclusion

These findings reveal disparities in TTT for osteosarcoma patients based on age, race/ethnicity, and tumor location, highlighting the need for equitable access to early care.

Abstract Image

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与骨肉瘤治疗延迟相关的因素和疾病特异性结局：一项基于人群的回顾性队列研究

在许多癌症类型中，肿瘤治疗的开始时间是影响疾病进展和生存结果的一个因素。我们的目的是确定与高级别骨肉瘤延迟治疗时间（TTT）相关的因素及其与疾病特异性生存（DSS）的关系。方法：使用ICD-O-3组织学代码9180/3-9194/3和原发部位代码C40.0-41.9，查询2000 - 2021年期间SEER数据库中活检确诊的高级别骨肉瘤病例。χ2、Kaplan-Meier log-rank检验和逐步多变量logistic回归使用SPSS完成，显著性设置为p。结果：Kaplan-Meier分析显示，TTT患者在1个月内的5年和10年DSS显著降低(p)。结论：这些发现揭示了骨肉瘤患者TTT在年龄、种族/民族和肿瘤位置上的差异，强调了公平获得早期护理的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.