Cardiovascular Risk Prediction in Older Adults.

IF 5.2 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2025-09-09 DOI:10.1007/s11883-025-01339-2

Lisandro D Colantonio, Vera Bittner

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Abstract

Purpose of review: This review examines cardiovascular disease (CVD) risk prediction models relevant to older adults, a rapidly expanding population with elevated CVD risk. It discusses model characteristics, performance metrics, and clinical implications.

Recent findings: Some models have been developed specifically for older adults, while several others consider a broader age range, including some older individuals. These models vary in terms of predictors, outcomes, horizon, and statistical approaches, with some accounting for competing risks and considering age-predictor interactions. Discrimination is generally acceptable and more modest in older versus younger individuals. Calibration shows great variation across populations. Accurate CVD risk prediction is essential to guide individualized prevention strategies and support shared decision-making in older adults. CVD risk prediction in this population is challenged by age-related CVD risk heterogeneity, elevated competing risk due to non-CVD mortality, and comorbidities. Further refinement by incorporating geriatric-specific factors may help to enhance discrimination.

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老年人心血管疾病风险预测。

综述目的：本综述探讨了与老年人相关的心血管疾病（CVD）风险预测模型，老年人是一个快速扩大的心血管疾病风险升高的人群。它讨论了模型的特点、性能指标和临床意义。最近的发现：一些模型是专门为老年人开发的，而其他一些模型考虑的年龄范围更广，包括一些老年人。这些模型在预测因素、结果、视界和统计方法方面各不相同，并考虑了一些竞争风险和年龄预测因素的相互作用。歧视通常是可以接受的，而且对老年人和年轻人的歧视更为温和。校准显示不同种群之间存在很大差异。准确的心血管疾病风险预测对于指导老年人的个体化预防策略和支持共同决策至关重要。这一人群的心血管疾病风险预测受到年龄相关的心血管疾病风险异质性、非心血管疾病死亡率导致的竞争风险升高和合并症的挑战。进一步细化纳入老年特定因素可能有助于加强歧视。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.