Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2025-09-09 DOI:10.1007/s00784-025-06527-7

Long Zhu, Si Liang, Yang Yang, Ziqi Su, Lijia Ou, Weimeng Zhang, Binjie Liu, Ousheng Liu, Hui Feng

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引用次数: 0

Abstract

Background: An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.

Methods: A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted. Periodontitis was defined according to CDC/AAP criteria, classification of periodontitis and severity of periodontitis according to the degree and amount of attachment loss in the interproximal site, and vitamin K intake was categorized using optimal cutoff value. Univariate and multivariate logistic regression analyses were used to investigate the association between vitamin K intake and the risk of periodontitis.

Results: Based on the information analysis of 2303 participants who met the inclusion criteria, the risk of periodontitis was lower in the elderly population with higher vitamin K intake. Especially, a statistically significant reduction in the prevalence of periodontitis was observed in elderly populations with vitamin K intake greater than 89.51 mg/d (OR = 0.648,95%Cl = 0.502-0.837, P value = 0.001) compared to those with vitamin K intake less than 89.51 mg/d. Subgroup analyses revealed that this association was more prominent in elderly people aged 60-69 years and 70-79 years, the female/male population, the Non-Hispanic White population, those with a poverty index of 1.3-3.5, education level over high school grad/GED, non-smokers, 1-5 drinks/month, non-alcohol drinkers, overweight, normal blood pressure and without diabetes.

Conclusion: Our research found a strong relationship between vitamin K intake and periodontitis among elderly people in the United States, suggesting vitamin K intake is a possible risk factor and may be a novel idea for the diagnosis and treatment of periodontitis.

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美国老年人维生素K摄入量与牙周炎之间的关系：NHANES数据的横断面分析

背景：越来越多的数据表明维生素K的摄入与牙周炎的进展密切相关。本研究的目的是利用美国国家健康与营养检查调查（NHANES）数据库的信息，估计维生素K摄入量是否与美国老年人牙周炎有关。方法：对2009-2014年NHANES数据库中美国60岁及以上成年人牙周指数和维生素K摄入量数据进行横断面分析。根据CDC/AAP标准对牙周炎进行定义，根据近端部位附着丧失的程度和数量对牙周炎进行分类和严重程度，并使用最佳临界值对维生素K摄入量进行分类。单变量和多变量logistic回归分析用于调查维生素K摄入量与牙周炎风险之间的关系。结果：根据2303名符合纳入标准的参与者的信息分析，维生素K摄入量较高的老年人患牙周炎的风险较低。特别是，与维生素K摄入量低于89.51 mg/d的老年人相比，维生素K摄入量大于89.51 mg/d的老年人牙周炎患病率有统计学意义的降低（OR = 0.648,95%Cl = 0.502-0.837， P值= 0.001）。亚组分析显示，这种关联在60-69岁和70-79岁的老年人、女性/男性人群、非西班牙裔白人人群、贫困指数为1.3-3.5的人群、高中毕业/GED以上的教育水平、不吸烟、每月饮酒1-5次、不饮酒、超重、血压正常和无糖尿病的人群中更为突出。结论：我们的研究发现维生素K摄入量与美国老年人牙周炎之间有很强的关系，提示维生素K摄入量可能是牙周炎的一个危险因素，可能为牙周炎的诊断和治疗提供新的思路。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.