Studying the relationship between allergo-inflammation and left atrium and pulmonary vein pathological changes in allergic asthma.

IF 2.1 4区 医学 Q3 ALLERGY
Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i5.1419
Deng Zou, Hualing Xiao, Seyyed Shamsadin Athari, Xiujuan Hu
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引用次数: 0

Abstract

Allergic asthma is an inflammatory airway disease influenced by genetic and environmental factors and orchestrated by imbalance between T helper 1 cell (Th1) and two immune responses. Inflammation contributes to pathological changes and remodeling in tissues such as the vascular, lung, heart, and beds. The purpose for this study was to evaluate the effects of allergic asthma on heart pathology and remodeling. In methodology, mice were allocated into two healthy and asthma groups, followed by the assessment of airway hyperresponsiveness (AHR), cell enumeration in bronchoalveolar lavage fluid (BALF), measurement of interleukin (IL)-4, IL-33, IL-5, interferon gamma (IFN-γ), and IL-13, total immunoglobulin E (IgE) levels, and analysis of remodeling factors. Also, gene expression analysis was performed for troponin, suppressor of mothers against decapentaplegic (SMAD)2, myocyte enhancer factor 2 (MEF-2), and SMAD3. Finally, histopathological study was conducted. The result revealed that asthma induction augmented AHR and elevated eosinophil percentage, elevated the levels of IL-13, IL-33, IL-5, IL-4, IgE, Helicobacter pylori (HP), and transforming growth factor beta (TGF-β), and the gene expression of SMAD3. Also, eosinophilic inflammation, goblet cell meta/hyperplasia, and mucus secretion were increased in asthmatic versus healthy mice. The level of IFN-γ was lower in the asthma compared to the control group; however, the expressions of troponin, SMAD2, and MEF-2 genes showed no significant differences. It was concluded that allergic asthma changed the balance between type 1 and 2 cytokines, which could possibly lead to profound effects on the cardiovascular system's structure and/or function.

变应性哮喘患者变应性炎症与左心房、肺静脉病变的关系研究。
过敏性哮喘是一种受遗传和环境因素影响,由辅助性T细胞(Th1)与两种免疫反应失衡所协调的炎症性气道疾病。炎症有助于血管、肺、心脏和床等组织的病理改变和重塑。本研究的目的是评估过敏性哮喘对心脏病理和重构的影响。在方法上,将小鼠分为健康组和哮喘组,随后评估气道高反应性(AHR),支气管肺泡灌洗液(BALF)细胞计数,测量白细胞介素(IL)-4、IL-33、IL-5、干扰素γ (IFN-γ)和IL-13,总免疫球蛋白E (IgE)水平,并分析重塑因子。同时,对肌钙蛋白、母亲抗十肢截瘫抑制因子(SMAD)2、肌细胞增强因子2 (MEF-2)和SMAD3进行基因表达分析。最后进行组织病理学研究。结果显示,哮喘诱导使AHR升高,嗜酸性粒细胞百分比升高,IL-13、IL-33、IL-5、IL-4、IgE、幽门螺杆菌(HP)、转化生长因子β (TGF-β)水平升高,SMAD3基因表达升高。此外,哮喘小鼠与健康小鼠相比,嗜酸性粒细胞炎症、杯状细胞间性增生和粘液分泌增加。哮喘组IFN-γ水平低于对照组;而肌钙蛋白、SMAD2和MEF-2基因的表达差异无统计学意义。由此得出结论,过敏性哮喘改变了1型和2型细胞因子之间的平衡,这可能对心血管系统的结构和/或功能产生深远影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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