Selective IgA deficiency and allergic diseases: Clinical and immunological evaluation.

IF 2.1 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i5.1374

Selami Ulaş, Serdar Al, Sezin Naiboğlu, Işılay Turan, Gülşah Kalay, Nermin Kapçı, Özge Türkyılmaz Uçar, Sibel Kaplan, Erkan Çakmak, Kübra Yırgın, Ahmet Sert, Meryem Özçelik, Burcu Çil, Şeyda Köse, Ilke Yıldırım, Simge Kılıçoğlu, Pınar Gökmirza Özdemir, Mehmet Halil Çeliksoy, Çiğdem Aydoğmuş

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引用次数: 0

Abstract

Purpose: We aimed to investigate allergic sensitization and associated factors in pediatric patients with selective immunoglobulin A deficiency (SIgAD) and to evaluate differences between allergic and nonallergic groups.

Methods: We analyzed 110 patients (aged 4-18 years) diagnosed with SIgAD at Çam and Sakura City Hospitals, Istanbul, between 2021 and 2024. Their demographic, clinical, and laboratory data were assessed.

Results: Allergic sensitization was detected in 62.7% of patients. Patients with allergic sensitization, family history of allergic diseases, eosinophilia, and elevated total immunoglobulin E (IgE) levels were significantly higher (P < 0.05). Immunglobulin M (IgM) levels were higher in the allergic group (P = 0.01), and they had lower neutrophil counts (P = 0.03). Allergic sensitization was lower in patients with autoimmune diseases (P = 0.03). In 60% of the patients, the main reason for presentation was recurrent infection.

Conclusion: Allergic sensitization with SIgAD is associated with genetic and immunological factors. A family history of allergic disease, eosinophilia, and elevated total IgE levels are important markers for the development of allergy. These findings highlight the need to closely monitor allergies in people with SIgAD.

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选择性IgA缺乏与过敏性疾病：临床和免疫学评价。

目的：研究选择性免疫球蛋白A缺乏症（SIgAD）患儿的过敏致敏及相关因素，并评价过敏组与非过敏组之间的差异。方法：我们分析了2021年至2024年间在Çam和伊斯坦布尔Sakura市医院诊断为SIgAD的110例患者（4-18岁）。评估了他们的人口统计学、临床和实验室数据。结果：62.7%的患者出现过敏反应。有过敏致敏、过敏性疾病家族史、嗜酸性粒细胞增多、总免疫球蛋白E （IgE）水平升高的患者显著高于其他患者（P < 0.05）。过敏组免疫球蛋白M （IgM）水平较高（P = 0.01），中性粒细胞计数较低（P = 0.03）。自身免疫性疾病患者的过敏致敏性较低（P = 0.03）。60%的患者表现为复发性感染。结论：SIgAD致敏与遗传和免疫因素有关。过敏性疾病家族史、嗜酸性粒细胞增多和总IgE水平升高是过敏发生的重要标志。这些发现强调了密切监测SIgAD患者过敏的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.