Deer Antler S-Adenosylmethionine Ameliorates Depression-Like Behaviors and Neuroinflammation in CUMS Mice

IF 5 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-09-10 DOI:10.1111/cns.70569

Yongjian Liu, Chenyang Han, Li Guo, Wenyan Li, Shasha wu, Jian Sheng, Liping Zhai, Heping Shen, Genghuan Wang

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Abstract

Aim

To investigate the effects and mechanisms of S-adenosylmethionine (SAM) from deer antler on improving depression-like behaviors in chronic unpredictable mild stress (CUMS) mice.

Methods

The CUMS method was used to establish a mouse depression model. The relationship between SAM and HIF-1α was analyzed by small molecule-protein docking and molecular dynamics simulation.

Results

Network pharmacology analysis showed that the effect of SAM is related to HIF-1α. When shRNA-HIF-1α was used to silence the expression of HIF-1α, the effect of SAM was inhibited. The improvement of depression-like behaviors in mice was not significant, and inflammatory factors were no longer further downregulated.

Conclusion

SAM can improve depression-like behaviors in CUMS mice and enhance their mobility. SAM inhibits neuroinflammation and glycolysis, and also suppresses the activation of microglia.

Abstract Image

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鹿茸s -腺苷蛋氨酸改善CUMS小鼠抑郁样行为和神经炎症

目的探讨鹿角s -腺苷蛋氨酸（SAM）对慢性不可预测轻度应激（CUMS）小鼠抑郁样行为的改善作用及其机制。方法采用CUMS法建立小鼠抑郁模型。通过小分子-蛋白对接和分子动力学模拟分析了SAM与HIF-1α之间的关系。结果网络药理学分析显示，SAM的作用与HIF-1α有关。用shRNA-HIF-1α沉默HIF-1α表达后，SAM的作用被抑制。小鼠抑郁样行为改善不显著，炎症因子不再进一步下调。结论SAM能改善CUMS小鼠抑郁样行为，增强其活动能力。SAM抑制神经炎症和糖酵解，也抑制小胶质细胞的激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.