Cortical Structure Abnormalities in Patients With Noise-Induced Hearing Loss: A Surface-Based Morphometry Study

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-09-10 DOI:10.1002/brb3.70813

Yunxin Li, Ranran Huang, Aijie Wang, Liping Wang, Minghui Lv, Xianghua Bao, Guowei Zhang

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引用次数: 0

Abstract

Objective

To investigate the characteristics of brain structures in patients with noise-induced hearing loss (NIHL) using source-based morphometry (SBM) and to evaluate the correlation between abnormal brain regions and clinical data.

Methods

High-resolution 3D T1 structural images were acquired from 81 patients with NIHL and 74 age- and education level-matched healthy controls (HCs). The clinical data of all subjects were collected, including noise exposure time, monaural hearing threshold weighted values (MTWVs), Mini-Mental State Examination (MMSE), and Hamilton Anxiety Scale (HAMA) scores. The FreeSurfer software was used to perform whole-brain SBM analysis based on T1 images. The cortical morphological parameters included cortical thickness, surface area, and cortical volume. The correlations between abnormal cortical morphological changes in brain regions and noise exposure time, MTWV (superiority), and HAMA scores were further analyzed.

Results

SBM results: NIHL patients had a greater cortical thickness in the left inferior parietal gyrus (IPG) and right superior parietal gyrus (SPG) compared with HCs (t = 2.916, p = 0.0474; t = 2.916, p = 0.0046); increased surface area and cortical volume were observed both in the left lateral occipital gyrus (LOG) in NIHL patients (t = 3.468, p = 0.0377; t = 3.091, p = 0.0002). Correlation analysis revealed that MTWV (superiority) was positively correlated with noise exposure time (r = 0.260, p = 0.019), and HAMA scores were negatively correlated with noise exposure time (r = −0.297, p = 0.007). Further, thicker cortical thickness in the left IPG and right SPG and increased cortical volume in the left LOG were negatively correlated with MTWV (superiority) (r = −0.238, p = 0.032; r = −0.255, p = 0.022; r = −0.272, p = 0.014). Increased cortical volume in the left LOG had a positive correlation with HAMA scores (r = 0.172, p = 0.032).

Conclusions

On the basis of the SBM method, we have discovered alterations in cortical morphology within the auditory–visual network regions such as the parietal and occipital lobes in NIHL patients. These findings suggest that auditory deprivation may initiate the restructuring of the auditory–visual cortex, providing new insights into the underlying mechanisms of brain activity abnormalities in NIHL patients. This study not only offers a new perspective on exploring brain structural anomalies associated with NIHL but also enhances our understanding of the neurobiology of NIHL.

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噪音性听力损失患者的皮质结构异常：一项基于表面形态学的研究

目的应用基于源的形态测量法（SBM）研究噪声性听力损失（NIHL）患者的脑结构特征，探讨异常脑区与临床资料的相关性。方法获取81例NIHL患者和74例年龄和教育程度匹配的健康对照（hc）的高分辨率3D T1结构图像。收集所有受试者的临床资料，包括噪声暴露时间、单耳听力阈值加权值（MTWVs）、简易精神状态检查（MMSE）和汉密尔顿焦虑量表（HAMA）评分。采用FreeSurfer软件基于T1图像进行全脑SBM分析。皮质形态学参数包括皮质厚度、表面积和皮质体积。进一步分析噪声暴露时间、MTWV（优越性）和HAMA评分与脑区皮质形态异常变化的相关性。结果SBM结果：NIHL患者左侧顶叶下回（IPG）和右侧顶叶上回（SPG）皮质厚度较hc患者显著增加（t = 2.916, p = 0.0474; t = 2.916, p = 0.0046）；NIHL患者左侧枕侧回表面积和皮质体积均增加（t = 3.468, p = 0.0377; t = 3.091, p = 0.0002）。相关分析显示，MTWV评分与噪声暴露时间呈正相关（r = 0.260, p = 0.019）， HAMA评分与噪声暴露时间呈负相关（r = - 0.297, p = 0.007）。此外，左侧IPG和右侧SPG皮质厚度的增加以及左侧LOG皮质体积的增加与MTWV呈负相关（r = - 0.238, p = 0.032; r = - 0.255, p = 0.022; r = - 0.272, p = 0.014）。左侧左脑皮质体积增加与HAMA评分呈正相关（r = 0.172, p = 0.032）。结论基于SBM方法，我们发现NIHL患者的顶叶和枕叶等听觉-视觉网络区域的皮层形态发生了变化。这些发现表明，听觉剥夺可能启动听觉-视觉皮层的重组，为NIHL患者大脑活动异常的潜在机制提供了新的见解。本研究不仅为探索与NIHL相关的脑结构异常提供了新的视角，而且提高了我们对NIHL神经生物学的认识。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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