Age-related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross-sectional trajectories and longitudinal validation

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-10 DOI:10.1002/alz.70675

Sungjoo Lee, Min Young Chun, Hyemin Jang, Michael Weiner, Suzanne E. Schindler, Daeun Shin, Heekyung Kang, Sohyun Yim, Eun Hye Lee, Kyunga Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo, the ADNI, A4, and K-ROAD studies

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引用次数: 0

Abstract

INTRODUCTION

We developed and validated age-related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals.

METHODS

We analyzed 849 CU Korean and 521 CU non-Hispanic White (NHW) participants after propensity score matching. Aβ PET trajectories were modeled using the generalized additive model for location, scale, and shape (GAMLSS) based on baseline data and validated with longitudinal data. Subgroup analyses examined apolipoprotein E (APOE) ε4 and sex effects.

RESULTS

Age-related centile curves of Aβ PET Centiloid values showed stable distributions in the lower percentiles, increasing with age in the upper percentiles. NHWs exhibited steeper Aβ accumulation trajectories, particularly among APOE ε4 carriers. Calibration with longitudinal data confirmed the reliability of this cross-sectional method.

DISCUSSION

We developed a statistical model of age-related Aβ PET trajectories using baseline data, validated with longitudinal data. NHWs exhibited steeper trajectories than Koreans, suggesting population-specific differences in Aβ accumulation.

Highlights

A generalized additive model for location, scale, and shape model was applied to examine age-related amyloid beta (Aβ) trajectories with baseline data.
Trajectories were validated using longitudinal data, confirming model reliability.
Non-Hispanic Whites exhibited steeper trajectories than Koreans, especially in apolipoprotein E ε4 carriers.
Our approach enables scalable modeling of Aβ dynamics for Alzheimer's disease prevention strategies.
Findings highlight the importance of multi-ethnic research in Aβ accumulation.

Abstract Image

查看原文本刊更多论文

年龄相关的β淀粉样蛋白动态模型的位置，规模和形状的广义加性模型（GAMLSS）在不同的人群：横截面轨迹和纵向验证

我们在认知未受损（CU）个体中使用统计模型开发并验证了与年龄相关的β淀粉样蛋白（a β）正电子发射断层扫描（PET）轨迹。方法通过倾向评分匹配，我们分析了849名CU韩国人和521名CU非西班牙裔白人（NHW）参与者。利用基于基线数据的位置、尺度和形状的广义加性模型（GAMLSS）对Aβ PET轨迹进行建模，并用纵向数据进行验证。亚组分析检测载脂蛋白E (APOE) ε4和性别影响。结果Aβ PET Centiloid值的年龄相关百分位曲线下百分位分布稳定，上百分位随年龄增长而增加。NHWs表现出更陡峭的Aβ积累轨迹，特别是在APOE ε4携带者中。用纵向数据标定证实了该横截面法的可靠性。我们利用基线数据建立了年龄相关的a β PET轨迹统计模型，并通过纵向数据进行验证。与韩国人相比，美国人表现出更陡峭的轨迹，这表明Aβ积累存在人群特异性差异。一个广义的位置、规模和形状模型被应用于检测与年龄相关的β淀粉样蛋白（Aβ）轨迹的基线数据。利用纵向数据对轨迹进行验证，确认了模型的可靠性。非西班牙裔白人表现出比韩国人更陡峭的轨迹，特别是在载脂蛋白E ε4携带者中。我们的方法可以为阿尔茨海默病预防策略提供可扩展的Aβ动力学建模。研究结果强调了多民族研究在Aβ积累中的重要性。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.