Dang Thi Ngoc Hoa, Nguyen Duc Hong, Pham Thang Long, Bui Le Thanh Nhan, Nguyen Ngoc Nam and Do Mai Nguyen
{"title":"Green electrochemical sensing of ampicillin using reduced graphene oxide-modified electrodes","authors":"Dang Thi Ngoc Hoa, Nguyen Duc Hong, Pham Thang Long, Bui Le Thanh Nhan, Nguyen Ngoc Nam and Do Mai Nguyen","doi":"10.1039/D5LF00127G","DOIUrl":null,"url":null,"abstract":"<p >A “green” electrochemical sensor for the detection of ampicillin (AMP) was developed using a reduced graphene oxide-modified glassy carbon electrode (rGO/GCE). The sensor exhibited good performance with a linear detection range from 0.02 μM to 2.56 μM and a low detection limit of 6.75 nM. Characterization of the rGO material was carried out using Fourier-transform infrared (FT-IR) and Raman spectroscopy, confirming the successful reduction of graphene oxide and the restoration of electrical conductivity. The rGO/GCE sensor demonstrated high selectivity, minimal interference from common compounds, and good repeatability, reproducibility and long-term stability. Real-sample analysis in spiked urine achieved recovery rates of 97–103%, validated by high-performance liquid chromatography (HPLC). The results highlight the rGO/GCE sensor as a sensitive, reliable, and cost-effective platform for AMP monitoring in pharmaceutical applications.</p>","PeriodicalId":101138,"journal":{"name":"RSC Applied Interfaces","volume":" 5","pages":" 1209-1219"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lf/d5lf00127g?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Applied Interfaces","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/lf/d5lf00127g","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A “green” electrochemical sensor for the detection of ampicillin (AMP) was developed using a reduced graphene oxide-modified glassy carbon electrode (rGO/GCE). The sensor exhibited good performance with a linear detection range from 0.02 μM to 2.56 μM and a low detection limit of 6.75 nM. Characterization of the rGO material was carried out using Fourier-transform infrared (FT-IR) and Raman spectroscopy, confirming the successful reduction of graphene oxide and the restoration of electrical conductivity. The rGO/GCE sensor demonstrated high selectivity, minimal interference from common compounds, and good repeatability, reproducibility and long-term stability. Real-sample analysis in spiked urine achieved recovery rates of 97–103%, validated by high-performance liquid chromatography (HPLC). The results highlight the rGO/GCE sensor as a sensitive, reliable, and cost-effective platform for AMP monitoring in pharmaceutical applications.
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