pH-Responsive ZIF-8 Precisely Induces Apoptosis of Oral Squamous Cell Carcinoma Over Orofacial Mesenchymal Stem/Stromal Cells

IF 2.6 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Pub Date : 2025-09-01 DOI:10.1016/j.joms.2025.06.074

Jessica Hao, Mehrnaz Zakershahrak, Fusun Ozer, Chider Chen

引用次数: 0

Abstract

The pH-responsive zeolite imidazolate framework-8 (ZIF-8) has recently gained attention as a drug delivery system for conventional cancer chemotherapeutics.¹ ZIF-8 may degrade in low pH conditions, such as the acidic tumor microenvironment (PH = 5.5), while remaining stable under physiological pH (PH = 7.4). In our previous study, ZIF-8 was shown to be capable of absorbing and releasing 5-fluorouracil (5-FU) in a controlled manner. Through in vitro cell biocompatibility studies, 5-FU

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ph响应的ZIF-8精确诱导口腔鳞状细胞癌的口面部间充质干细胞/基质细胞凋亡

ph响应型沸石咪唑酸框架-8 （ZIF-8）最近作为常规癌症化疗的药物递送系统受到关注ZIF-8可能在低pH条件下降解，如酸性肿瘤微环境（pH = 5.5），而在生理pH （pH = 7.4）下保持稳定。在我们之前的研究中，ZIF-8能够以可控的方式吸收和释放5-氟尿嘧啶（5-FU）。通过体外细胞生物相容性研究，5-FU

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来源期刊

Journal of Oral and Maxillofacial Surgery 医学-牙科与口腔外科

CiteScore

4.00

自引率

5.30%

发文量

审稿时长

41 days

期刊介绍： This monthly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments and diagnostic equipment and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association.