Oral Microbiome as a Therapeutic Modulator in OSCC: From Mechanism to Immunotherapy

IF 2.6 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Pub Date : 2025-09-01 DOI:10.1016/j.joms.2025.06.111

Tal Capucha DMD, PhD, OMFS, Chaim Ohayon DMD, OMFS, Adi Rachmiel DMD, PhD, OMFS, Omri Emodi MD, DMD, Naama Geva-Zatorsky PhD

引用次数: 0

Abstract

Oral squamous cell carcinoma (OSCC) represents approximately 4.5% of all malignancies worldwide and is characterized by a stagnant 5-year survival rate of 63%, underscoring the need for deeper insights into its pathogenesis and treatment. Emerging evidence suggests that the oral microbiome plays a pivotal role in shaping the tumor microenvironment (TME), modulating immune responses and influencing treatment efficacy. This study investigates the cellular and molecular interactions among the oral

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口腔微生物组作为OSCC的治疗调节剂：从机制到免疫治疗

口腔鳞状细胞癌（OSCC）约占全球所有恶性肿瘤的4.5%，其特点是5年生存率停滞不前，为63%，强调需要更深入地了解其发病机制和治疗。越来越多的证据表明，口腔微生物组在塑造肿瘤微环境（TME）、调节免疫反应和影响治疗效果方面起着关键作用。本研究探讨了口腔黏膜细胞和分子间的相互作用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral and Maxillofacial Surgery 医学-牙科与口腔外科

CiteScore

4.00

自引率

5.30%

发文量

审稿时长

41 days

期刊介绍： This monthly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments and diagnostic equipment and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association.