Toward Improved Therapy for Oral Cancer: Dissecting the Tumor Microenvironment at the Single-Cell Level With Machine Learning Predicts Novel Therapeutic Targets in OSCC

IF 2.6 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Pub Date : 2025-09-01 DOI:10.1016/j.joms.2025.06.075

Michael E. Troka, James Gates DMD, MD FACS, Pennsylvania

引用次数: 0

Abstract

Of “The Patients We Serve”, oral squamous cell carcinoma (OSCC) is one of the most devastating and difficult diseases to treat. It presents a significant therapeutic challenge: treating both the tumor itself and the microenvironment in which it develops. Clinically, this manifests as high post-surgical recurrence rates – 28% in early stages and up to 60% in late stage. It is likely that the tumor-promoting microenvironment that remains, even after histologically negative margins, contributes to

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改善口腔癌的治疗：在单细胞水平上用机器学习分析肿瘤微环境预测OSCC的新治疗靶点

在我们服务的患者中，口腔鳞状细胞癌（OSCC）是最具破坏性和最难治疗的疾病之一。它提出了一个重大的治疗挑战：既要治疗肿瘤本身，又要治疗肿瘤发展的微环境。临床表现为术后复发率高，早期为28%，晚期可达60%。这很可能是肿瘤促进微环境仍然存在，即使在组织学阴性边缘，有助于

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来源期刊

Journal of Oral and Maxillofacial Surgery 医学-牙科与口腔外科

CiteScore

4.00

自引率

5.30%

发文量

审稿时长

41 days

期刊介绍： This monthly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments and diagnostic equipment and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association.