Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in oral lichen planus patients with normocytosis

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-08-16 DOI:10.1016/j.jds.2025.08.003

Julia Yu-Fong Chang , Yu-Hsueh Wu , Yi-Pang Lee , Yi-Ping Wang , Andy Sun , Chun-Pin Chiang

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引用次数: 0

Abstract

Background/purpose

Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether the 474 oral lichen planus (OLP) patients with normocytosis (so-called normocytosis/OLP patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 588 healthy control subjects or 588 OLP patients.

Materials and methods

Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 588 OLP patients, 474 normocytosis/OLP patients, and 588 healthy control subjects were measured and compared.

Results

We found that 14.3 %, 12.7 %, 4.0 %, 1.5 %, 16.0 %, and 19.8 % of the 474 normocytosis/OLP patients had blood hemoglobin (Hb) and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Furthermore, the 474 normocytosis/OLP patients had significantly higher frequencies of blood Hb and serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 588 healthy control subjects (all P-values <0.05). On the contrary, the 474 normocytosis/OLP patients had significantly lower frequencies of blood Hb and serum vitamin B12 deficiencies and hyperhomocysteinemia than the overall 588 OLP patients (all P-values <0.05).

Conclusion

We conclude that there are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in normocytosis/OLP patients than in healthy control subjects. On the contrary, normocytosis/OLP patients do have significantly lower frequencies of blood Hb and vitamin B12 deficiencies and hyperhomocysteinemia than overall OLP patients.

查看原文本刊更多论文

口腔扁平苔藓伴正常细胞增多症患者的贫血、血液病缺乏、高同型半胱氨酸血症和胃壁细胞抗体阳性

背景/目的细胞增多症被定义为平均红细胞体积（MCV）在80 fL到99.9 fL之间。本研究评估了474例口腔扁平苔藓（OLP）患者（所谓的正常细胞增多症/OLP患者）是否比588名健康对照者或588名OLP患者有明显更高的贫血、血液病缺乏、高同型半胱氨酸血症和血清胃壁细胞抗体（GPCA）阳性的频率。材料与方法测定588例OLP患者、474例正常细胞增多症/OLP患者和588例健康对照者全血细胞计数、血清铁、维生素B12、叶酸、同型半胱氨酸和GPCA水平并进行比较。结果474例正常细胞增多症/OLP患者中分别有14.3%、12.7%、4.0%、1.5%、16.0%和19.8%存在血红蛋白（Hb）、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性。此外，474例正常细胞增多症/OLP患者血Hb和血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性的频率显著高于588例健康对照（p值均为0.05）。相反，474例正常细胞增多症/OLP患者的血Hb和血清维生素B12缺乏症和高同型半胱氨酸血症的频率明显低于总体588例OLP患者（p值均为0.05）。结论正常细胞增多症/OLP患者的贫血、血清铁、维生素B12和叶酸缺乏、高同型半胱氨酸血症和血清GPCA阳性发生率明显高于健康对照组。相反，正常细胞增多症/OLP患者的血Hb和维生素B12缺乏症以及高同型半胱氨酸血症的发生率明显低于整体OLP患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.