An injectable hyaluronic acid-based hydrogel for the treatment of breast cancer

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-05 DOI:10.1016/j.colsurfb.2025.115100

Xin Shen , Yang Li , Xinru Kang , Chenhui Zhu , Zhiguang Duan , Rongzhan Fu

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Abstract

In this study, we develop a hyaluronic-tannic acid (HA-TA) hydrogel loaded with Cu nanoparticles attach to MXene (MXene@Cu) to explore its potential as a targeted breast cancer treatment. The MXene@Cu nanosheets exhibit activity in depleting glutathione (GSH) and inducing reactive oxygen species (ROS) through the Fenton-like reaction. They can down-regulate the activity of glutathione peroxidase 4 (GPX4), leading to the accumulation of lipid peroxides (LPO) and inducing ferroptosis in tumor cells. GSH depletion enhances both ferroptosis and apoptosis efficacy. Additionally, under photothermal therapy (PTT), accelerated GSH consumption and the Fenton-like reaction further amplify ferroptosis and apoptosis. Injectable hyaluronic acid-based hydrogel adheres to tumor tissue, enabling local treatment and precise PTT, thereby improving treatment efficiency. In summary, the HA-TA/MXene@Cu hydrogel synergistically enhance oxidative stress and consume GSH, triggering ferroptosis and amplifying photothermal-mediated apoptosis, leading to potent inhibition of breast cancer growth. This innovative therapeutic modality presents a promising approach for precise and effective local breast cancer treatment.

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一种注射用透明质酸水凝胶，用于治疗乳腺癌

在这项研究中，我们开发了一种透明质酸-单宁酸（HA-TA）水凝胶，将Cu纳米颗粒附着在MXene上（MXene@Cu），以探索其作为靶向乳腺癌治疗的潜力。MXene@Cu纳米片具有消耗谷胱甘肽（GSH）和通过芬顿样反应诱导活性氧（ROS）的活性。它们可以下调谷胱甘肽过氧化物酶4 （glutathione peroxidase 4, GPX4）的活性，导致脂质过氧化物（脂质过氧化物）的积累，诱导肿瘤细胞铁下垂。GSH耗竭增强铁下垂和细胞凋亡的作用。此外，在光热治疗（PTT）下，GSH消耗的加速和fenton样反应进一步放大了铁下垂和细胞凋亡。可注射的透明质酸水凝胶粘附在肿瘤组织上，实现局部治疗和精确PTT，从而提高治疗效率。综上所述，HA-TA/MXene@Cu水凝胶协同增强氧化应激和消耗GSH，触发铁凋亡并放大光热介导的细胞凋亡，从而有效抑制乳腺癌的生长。这种创新的治疗方式为精确有效的局部乳腺癌治疗提供了一种有希望的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.