Molecularly imprinted polymers in soft and flexible surfaces for biomedical applications

IF 4.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-09-07 DOI:10.1016/j.sna.2025.117043

Hichem Moulahoum, Derya Nil Kisin, Didem Remziye Fidan, Sude Yilmaz, Faezeh Ghorbanizamani

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引用次数: 0

Abstract

The integration of molecularly imprinted polymers (MIPs) with soft and flexible substrates represents a promising yet underexplored approach in the field of wearable and implantable biosensors. While MIPs offer high chemical stability and selective molecular recognition akin to biological receptors, soft materials enable real-time, conformal sensing in dynamic and complex environments. This review critically examines recent advances in MIP fabrication and deposition strategies, as well as the development of flexible substrates, including polymers, textiles, paper, and bio-derived materials. Emphasis is placed on methods that merge imprinting with stretchable, biocompatible, and multifunctional materials for biomedical monitoring. Particular attention is paid to the challenges in imprinting large biomolecules and achieving scalable, durable sensor designs. By highlighting both achievements and current limitations, this work provides a roadmap for the design of next-generation wearable biosensors that integrate smart recognition with adaptable mechanical performance.

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用于生物医学应用的柔软和柔性表面的分子印迹聚合物

分子印迹聚合物（MIPs）与柔软和柔性基板的集成代表了可穿戴和可植入生物传感器领域的一种有前途但尚未开发的方法。虽然mip具有类似于生物受体的高化学稳定性和选择性分子识别，但软材料能够在动态和复杂环境中实现实时、保形传感。本文综述了MIP制造和沉积策略的最新进展，以及柔性基板的发展，包括聚合物、纺织品、纸张和生物衍生材料。重点放在将印迹与可拉伸、生物相容性和多功能材料合并用于生物医学监测的方法上。特别关注的是在印迹大型生物分子和实现可扩展的，耐用的传感器设计的挑战。通过强调成就和当前的局限性，这项工作为下一代可穿戴生物传感器的设计提供了路线图，该传感器将智能识别与适应性机械性能相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...