Transient receptor potential (TRP) in neuroglia and their role in pain. Brief review

Abstract

Neuroglia has an essential role in pain perception that goes beyond neuropathic pain and is now considered to play a major role in the processes of sensitization, establishment of chronic pain and nociplasticity. In this intricate process of plasticity and neuroinflammation, there are multiple receptors, one of them the transient receptor potential (TRP) that has different types and subtypes in relation to their amino acids. These receptors vary in each person in relation to their sex, hormonal profile, genetics and age, which may explain the variability in pain perception. There are some treatments that intervene in these receptors and many more are in development, which could become a novel and interesting alternative therapy.