Widely Distributed Pigeon Paramyxovirus Sub-Genotypes Pose a Risk to Immunocompromised Humans.

IF 2.3 2区 农林科学 Q3 INFECTIOUS DISEASES
Celia Abolnik, Michaela Hayes
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引用次数: 0

Abstract

Introduction: Pigeon paramyxovirus type 1 (PPMV-1) is an antigenic variant of Avian Orthoavulavirus 1 (AOAV-1) (Newcastle disease virus) with a global distribution that causes lethal infections in pigeon and dove species. AOAV-1's infecting humans normally cause mild, self-limiting conjunctivitis, but since 2003, PPMV-1 has been associated with an increased number of severe and lethal respiratory and neurological infections in immunocompromised persons in the Netherlands, the USA, France, China and Australia.

Methods: PPMV-1's isolated from free-living pigeons and doves across South Africa from 2012 to 2024 were sequenced using conventional or next generation technologies. Maximum likelihood and time-scaled phylogenetic analyses were conducted. Cases of human infections with AOAV-1 were reviewed, and where the genotypes were not previously assigned, the sequence data were re-analysed for classification purposes.

Results: PPMV-1 sub-genotype VI.2.1.1.2.1, present in South Africa since at least 2005, continued to circulate in 2021. Sub-genotype VI.2.1.1.2.2, that is widely distributed across Europe, Asia and Australia, was identified in South Africa for the first time, with introduction estimated around September 2017 (95% HPD January 2016-June 2019). Previously unclassified viruses causing lethal human infections in the Netherlands (2003), the USA (2007) and France (2021) were identified as sub-genotypes VI.2.1.1.2.2, VI.2.1.1.1 and XXI.1.1, respectively.

Conclusions: Five recorded AOAV-1-associated human fatalities since 1953 were all caused by PPMV-1. Three out of the five human fatalities, plus one seriously ill survivor, were associated with sub-genotype VI.2.1.1.2.2 viruses, and sub-genotypes VI.2.1.1.1 and XXI.1.1 each caused one human death. PPMV-1's, found widely in pigeons and doves, pose a serious health risk to immunocompromised persons.

广泛分布的鸽子副粘病毒亚基因型对免疫功能低下的人类构成风险。
简介:鸽子副粘病毒1型(PPMV-1)是禽原avulvirus 1 (AOAV-1)(新城疫病毒)的一种抗原变异,在全球分布,可引起鸽子和鸽子的致命感染。AOAV-1感染人类通常会引起轻度自限性结膜炎,但自2003年以来,PPMV-1在荷兰、美国、法国、中国和澳大利亚的免疫功能低下人群中与严重和致命的呼吸道和神经系统感染数量增加有关。方法:采用常规或下一代技术对2012 - 2024年从南非自由生活的鸽子和鸽子中分离的PPMV-1进行测序。进行了最大似然和时间尺度的系统发育分析。对人感染AOAV-1病例进行了回顾,对先前未指定基因型的病例重新分析序列数据以进行分类。结果:至少自2005年以来在南非存在的PPMV-1亚基因型VI.2.1.1.2.1在2021年继续传播。广泛分布于欧洲、亚洲和澳大利亚的VI.2.1.1.2.2亚基因型首次在南非被发现,估计在2017年9月左右引入(95% HPD于2016年1月至2019年6月)。以前在荷兰(2003年)、美国(2007年)和法国(2021年)引起致命人类感染的未分类病毒分别被确定为亚基因型VI.2.1.1.2.2、VI.2.1.1.1和XXI.1.1。结论:1953年以来记录的5例与aoav -1相关的人类死亡病例均由PPMV-1引起。在5例死亡病例中,3例和1例重病幸存者与VI.2.1.1.2.2亚基因型病毒有关,VI.2.1.1.1和XXI.1.1亚基因型各造成1人死亡。PPMV-1广泛存在于鸽子和鸽子中,对免疫功能低下的人构成严重的健康风险。
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来源期刊
Zoonoses and Public Health
Zoonoses and Public Health 医学-传染病学
CiteScore
5.30
自引率
4.20%
发文量
115
审稿时长
6-12 weeks
期刊介绍: Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.
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