Long-term cardiovascular outcomes and mortality following Kawasaki disease: A systematic review and meta-analysis.

IF 2 4区医学 Q2 PEDIATRICS

Paediatrics & child health Pub Date : 2025-03-27 eCollection Date: 2025-08-01 DOI:10.1093/pch/pxaf003

Francis Lao, Cal H Robinson, Dorota Borovsky, Joycelyne Ewusie, Karen Beattie, Michelle Batthish

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引用次数: 0

Abstract

Objectives: To determine if children with Kawasaki disease (KD) are at an increased long-term risk of cardiovascular disease and mortality.

Methods: A systematic review and meta-analysis was performed. A systematic search of MEDLINE, EMBASE, CINAHL, Cochrane, and Web of Science databases was performed through 2022. English-language publications, patients 0 to 18 years at KD diagnosis, minimum follow-up >1 year, and ≥10 patients included. Of 5072 articles, 181 were included. Cardiovascular events and mortality were extracted and pooled for analysis. Meta-analyses and meta-regression analyses were performed. The primary outcome of interest was the incidence of specific cardiovascular events (composite of myocardial infarction, heart failure or cardiac arrest) and all-cause mortality. Secondary outcomes included the incidence of occlusive coronary events, myocardial infarction, heart failure, cardiac arrest, non-coronary artery bypass grafting (CABG) coronary revascularization procedures, and CABG.

Results: Cardiovascular events occurred in 0.85% of children during study follow-up. The incidence rate of cardiovascular events was 370 per 100,000 person-years. Mortality occurred in 0.24% of children during study follow-up. The incidence rate of mortality was 117 per 100,000 person-years.

Conclusions: There is a low incidence of cardiovascular events and mortality following childhood KD diagnosis. Further studies are needed to better define this long-term risk.

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川崎病的长期心血管结局和死亡率：一项系统回顾和荟萃分析

目的：确定川崎病（KD）患儿患心血管疾病和死亡的长期风险是否增加。方法：进行系统综述和荟萃分析。对MEDLINE、EMBASE、CINAHL、Cochrane和Web of Science数据库进行了系统搜索，直至2022年。英文出版物，诊断为KD的患者年龄为0 ~ 18岁，最低随访时间为1 ~ 10年，患者≥10例。5072篇文章中，181篇被纳入。心血管事件和死亡率被提取并汇总进行分析。进行meta分析和meta回归分析。研究的主要终点是特定心血管事件（心肌梗死、心力衰竭或心脏骤停）的发生率和全因死亡率。次要结局包括闭塞性冠状动脉事件、心肌梗死、心力衰竭、心脏骤停、非冠状动脉旁路移植术（CABG）冠状动脉血运重建术和CABG的发生率。结果：0.85%的儿童在研究随访期间发生心血管事件。心血管事件发生率为每10万人年370例。在研究随访期间，儿童死亡率为0.24%。死亡率为每10万人年117人。结论：儿童KD诊断后心血管事件发生率和死亡率较低。需要进一步的研究来更好地定义这种长期风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Paediatrics & child health 医学-小儿科

CiteScore

2.10

自引率

5.30%

发文量

208

审稿时长

>12 weeks

期刊介绍： Paediatrics & Child Health (PCH) is the official journal of the Canadian Paediatric Society, and the only peer-reviewed paediatric journal in Canada. Its mission is to advocate for the health and well-being of all Canadian children and youth and to educate child and youth health professionals across the country. PCH reaches 8,000 paediatricians, family physicians and other child and youth health professionals, as well as ministers and officials in various levels of government who are involved with child and youth health policy in Canada.