First synergistic application of nanocarrier-loaded metaflumizone and parasitic wasps: A high-efficiency green pest control strategy.

IF 4 1区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pesticide Biochemistry and Physiology Pub Date : 2025-11-01 Epub Date: 2025-08-07 DOI:10.1016/j.pestbp.2025.106625

Shangyuan Wu, Qinhong Jiang, Leiyang Li, Ying Wei, Jinhong Zhou, Meizhen Yin, Jie Shen, Yufang Meng, Shuo Yan, Hu Li

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引用次数: 0

Abstract

The improper use of chemical pesticides threatens ecosystems and human health, highlighting the need for sustainable alternatives. Nano-pesticides and biological control agents offer a solution, and their combination can reduce pesticide usage and improve pest control efficacy. This study utilized a star polycation (SPc) to prepare a metaflumizone nano-pesticide and combined it with the egg parasitoid (Telenomus remus) for synergistic pest management. SPc exhibited minimal toxicity to T. remus at working concentrations but caused mortality at extremely high doses, with an oral LC₅₀ of 4.23 mg/mL. RNA-seq analysis revealed that the stress responses in T. remus induced by SPc included enhanced phagocytosis, exocytosis and energy synthesis. The SPc self-assembled with metaflumizone through hydrogen bonding and Van der Waals forces, reduced the particle size to the nanoscale (467.25 nm). The nano-pesticide increased stomach toxicity against Spodoptera litura by over 30 %, which showed no significant toxicity to T. remus eggs or adults and maintained parasitic capacity. The combined application of metaflumizone/SPc complex and T. remus achieved over 90 % pest control efficacy, providing a novel and effective strategy for sustainable pest management.

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首次协同应用纳米载体载metaflumizone和寄生蜂：一种高效的绿色害虫防治策略。

化学农药的不当使用威胁着生态系统和人类健康，因此需要可持续的替代品。纳米农药与生物防治剂结合使用，可以减少农药用量，提高害虫防治效果。本研究利用星形多阳离子（SPc）法制备了一种metaflumizone纳米农药，并将其与卵类拟寄生虫（Telenomus remus）联合施用，实现了害虫的协同治理。SPc在工作浓度下对雷氏弓形虫的毒性很小，但在极高剂量下会导致死亡，口服LC50为4.23 mg/mL。RNA-seq分析显示，SPc诱导的应激反应包括吞噬、胞吐和能量合成增强。SPc通过氢键和范德华力与甲基氟化酮自组装，将颗粒尺寸减小到纳米级（467.25 nm）。纳米农药对斜纹夜蛾的胃毒作用增强30%以上，对斜纹夜蛾卵和成虫无明显毒性，维持了其寄生能力。甲氟咪唑/SPc复合药剂与灰除虫联合施用，防治效果达90%以上，为灰除虫可持续治理提供了一种新颖有效的防治策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pesticide Biochemistry and Physiology 生物-昆虫学

CiteScore

7.00

自引率

8.50%

发文量

238

审稿时长

4.2 months

期刊介绍： Pesticide Biochemistry and Physiology publishes original scientific articles pertaining to the mode of action of plant protection agents such as insecticides, fungicides, herbicides, and similar compounds, including nonlethal pest control agents, biosynthesis of pheromones, hormones, and plant resistance agents. Manuscripts may include a biochemical, physiological, or molecular study for an understanding of comparative toxicology or selective toxicity of both target and nontarget organisms. Particular interest will be given to studies on the molecular biology of pest control, toxicology, and pesticide resistance. Research Areas Emphasized Include the Biochemistry and Physiology of: • Comparative toxicity • Mode of action • Pathophysiology • Plant growth regulators • Resistance • Other effects of pesticides on both parasites and hosts.