Evaluation of Thiol/Disulfide Homeostasis and İschemia-modified Albumin Levels in Symptomatic Dermographism.

IF 1.3 4区医学 Q4 DERMATOLOGY

Indian Journal of Dermatology Pub Date : 2025-09-01 DOI:10.4103/ijd.ijd_770_24

Mahmut Sami Metin, Tuğba Tehçi, İlkay Kolukırık, Serkan Akoğul, Ümran Öner, Zühal Metin

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引用次数: 0

Abstract

Background: Symptomatic dermographism (SD) is the most common chronic inducible urticaria (CIndU) type. Thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels are indicators of oxidative stress.

Aim: Our study aims to investigate the role of thiol/disulfide balance and IMA levels in the pathogenesis of SD. This focus guides our research and helps us to better understand the disease.

Materials and methods: This cross-sectional study, conducted with utmost care and precision, included 50 SD patients and 50 healthy volunteers. The patients and controls were meticulously evaluated regarding IMA, native thiol, total thiol, and disulfide levels and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios, ensuring a thorough and reliable understanding of the data.

Results: In our study, the patient group demonstrated significantly higher levels of native thiol, total thiol, disulfide, and IMA values than the control group (P < 0.05).

Conclusions: In patients with SD, impaired TDH and increased IMA suggest that oxidative stress may play a significant role in the disease pathogenesis, underscoring the importance of our findings.

Abstract Image

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评价症状性皮肤病中硫醇/二硫稳态和İschemia-modified白蛋白水平。

背景：症状性皮肤特征（SD）是最常见的慢性诱导性荨麻疹（CIndU）类型。硫醇/二硫稳态（TDH）和缺血修饰白蛋白（IMA）水平是氧化应激的指标。目的：探讨巯基/二硫平衡和IMA水平在SD发病机制中的作用。这一重点指导着我们的研究，帮助我们更好地了解这种疾病。材料和方法：这项横断面研究非常小心和精确地进行，包括50名SD患者和50名健康志愿者。仔细评估患者和对照组的IMA、天然硫醇、总硫醇和二硫水平，以及二硫/天然硫醇、二硫/总硫醇和天然硫醇/总硫醇比率，确保对数据的全面和可靠的理解。结果：在我们的研究中，患者组的天然硫醇、总硫醇、二硫和IMA值明显高于对照组（P < 0.05）。结论：在SD患者中，TDH受损和IMA升高提示氧化应激可能在疾病发病机制中发挥重要作用，强调了我们研究结果的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Dermatology Medicine-Dermatology

CiteScore

1.80

自引率

0.00%

发文量

217

审稿时长

47 weeks

期刊介绍： The journal publishes information related to skin-pathology and different modes of therapeutics, including dermatosurgery and cosmetic dermatology. Likewise, it carries articles on leprosy, STI and HIV/AIDS. The editorial board encourages the authors to publish articles addressing emerging techniques and developments in the subject specialty, in the form of Original investigations, Narrative and Systematic Reviews as well as Case Reports. The journal aims at publishing Editorials and Commentaries from eminent personalities on a regular basis.